About Humalog U-200 KwikPen^®

You may have been taking a long-acting insulin for a while now. So why did your doctor prescribe another insulin? Well, it's to help control the blood sugar "spikes" that happen naturally when you eat. Everyone gets them, but when you have diabetes you may need extra help controlling them. That's where Humalog comes in.

Humalog is different than your long-acting insulin. Long-acting insulin helps control your blood sugar throughout the whole day.

Select Safety Information

Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

Humalog U-200 KwikPen

Humalog U-200 KwikPen is a small, lightweight pen that’s prefilled with Humalog U-200 mealtime insulin. Plus, since it shouldn't be refrigerated after the first use^*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it's the size of a marker.
^*Once you start using Humalog U-200 KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains insulin.

Humalog U-200 KwikPen is the same familiar design as the Humalog U-100 KwikPen. When comparing the two, you'll notice some meaningful differences and similarities:

Differences

Humalog U-200 KwikPen holds double the mealtime insulin^* as U-100 pens.
With Humalog U-200 KwikPen, you'll change pens half as often^*,†.
With Humalog U-200 KwikPen, you will need fewer pens per month^*.

Similarities

It is the same size as the Humalog U-100 KwikPen
No dose calculations or conversions are needed to use Humalog U-200 KwikPen^‡.
Once your KwikPen is opened and used for the first time, it should not be refrigerated and can be used for up to 28 days. After 28 days, the KwikPen should be discarded even if insulin remains.

^*As compared with U-100 mealtime insulin pens.
^†Once opened, Humalog U-200 KwikPen should be thrown away after 28 days, even if insulin remains.
^‡Please see Instructions for Use included with your pen or click here.

Learn how to use Humalog U-200 KwikPen.

SAFETY SUMMARY

Warnings -

Do not take Humalog or Insulin Lispro Injection if you have:

symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro products or any of their ingredients.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

prefilled pen for use by a single patient
cartridges
reusable pen that works with Lilly 3mL cartridges
needles
syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious.

Humalog and Insulin Lispro Injection may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

Low blood sugar. This can cause:
- dizziness or light-headedness
- headache
- shakiness
- irritability
- sweating
- blurred vision
- fast heartbeat
- mood change
- confusion
- slurred speech
- anxiety
- hunger
If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
Severe allergic reaction.
Get emergency help right away if you have:
- a rash over your whole body
- sweating
- extreme drowsiness
- swelling of your face, tongue, or throat
- trouble breathing
- a faint feeling
- dizziness
- a fast heartbeat
- shortness of breath
- confusion
Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or "TZDs," with insulin lispro products may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with these insulin lispro products. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product.
High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.

Common side effects

The most common side effects of Humalog and Insulin Lispro Injection are:

low blood sugar
reactions where you have injected insulin
swelling of your hands or feet
itching

allergic reactions
changes in fat tissue where you have injected insulin
weight gain
rash

These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:

about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
about any other prescription medicines you take, especially ones called TZDs.
about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.

How to take

Read the Instructions for Use that come with your Humalog or Insulin Lispro Injection. Be sure to take your insulin lispro product and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.

Before injecting your insulin lispro product

You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:

Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you re-use needles.
Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

When you are ready to inject

Inject Humalog or Insulin Lispro Injection, under your skin within 15 minutes before or right after you eat a meal.

Staying safe while taking your insulin lispro product

To stay safe while taking your insulin, be sure to never inject Humalog U-200 in your vein, muscle, or with an insulin pump. Also be sure not to:

mix Humalog U-200 with other insulins or liquids.
drive or use heavy machinery until you know how your insulin lispro product affects you.
drink alcohol or use other medicines that contain alcohol when taking your insulin lispro product.

Learn more

Humalog and Insulin Lispro are prescription medicines. For more information, call 1-800-545-5979.

This summary provides basic information about Humalog and Insulin Lispro Injection. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other health care provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.

HI SP CON BS 14SEP2022

Humalog^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

INDICATIONS

Humalog^® (HU-ma-log) and Insulin Lispro Injection are fast-acting insulins used to control high blood sugar in adults and children with diabetes.

Humalog comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. The dose window on the pen shows your insulin dose.
It is not known if Humalog or Insulin Lispro Injection are safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. There were no studies done with these insulins in these groups of children. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

All Humalog and Insulin Lispro Injection products contain insulin lispro.

About Humalog U-200 KwikPen®