
Why Humalog® U-200 KwikPen®?
You may have been taking a long-acting insulin for a while now. So why did your doctor prescribe another insulin? Well, it’s to help control the blood sugar spikes that happen naturally when you eat. Everyone gets them, but when you have diabetes you may need extra help controlling them. That’s where Humalog comes in.
Humalog is different than your long-acting insulin. Long-acting insulin helps control your blood sugar throughout the whole day.
Humalog is fast-acting insulin—it helps control the blood sugar spikes that happen naturally when you eat.
Humalog is available in the Humalog U-200 KwikPen, which is portable. And, since it shouldn’t be refrigerated after the first use, you can take it just about anywhere.
Getting Started on Humalog® U-200
Here are a few things to remember when getting started with Humalog U-200:
- Humalog U-200 is taken 15 minutes before or immediately after a meal
- Low blood sugar (hypoglycemia) is the most common side effect of Humalog and may be severe and cause unconsciousness, seizures, and death
- You can treat low blood sugar promptly by eating or drinking something containing sugar (like jelly beans or fruit juice) to get your blood sugar back into a safe range
- Make sure you understand how many units your doctor wants you to take and with what meals

Easy to deliver the dose
Easy to set and see the dose
Easy to dial up and back down for dose selection
Using Humalog® U-200 KwikPen®
Humalog U-200 KwikPen is a small, lightweight pen that’s prefilled with Humalog U-200 mealtime insulin. It’s portable and can help you inject your mealtime insulin simply and discreetly when you’re away from home.
After you use your pen for the first time, you don’t have to put it back in the refrigerator. Simply drop it into your purse or pocket until you need it again. Remember, always carry an extra pen with you.
LEARN HOW TO USEHumalog U-200 KwikPen has the same familiar design as the Humalog U-100 KwikPen you may currently be using. When comparing the two, you'll notice some meaningful differences and similarities:
Differences
- It holds double the mealtime insulin*
- You will be able to change pens half as often*†
- You will need fewer pens per month*
Similarities
- It is the same size as Humalog U-100 KwikPen
- It works just like your Humalog U-100 KwikPen and no dose conversions are necessary‡
- Once your KwikPen is opened and used for the first time, it should not be refrigerated and can be used for up to 28 days. After 28 days, the KwikPen should be discarded even if insulin remains.
*As compared with U-100 mealtime insulin pens.
†Once opened, Humalog U-200 KwikPen should be thrown away after 28 days, even if insulin remains.
‡Please see Instructions for Use included with your pen or click here.
How to use Humalog® U-200 KwikPen®
These are not the full instructions. Please see the Instructions for Use included with your pen for full instructions.
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Introduction
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Step 1: Preparing Your Humalog U-200 KwikPen
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Step 2: Priming Your Humalog U-200 KwikPen
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Step 3: Selecting Your Dose
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Step 4: Giving Your Injection
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Step 5: After Your Injection
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Step 6: Disposing of Your Pens and Needles
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Step 7: Storing Your Pen
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Step 8: General Information
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Step 9: Important Safety Information
The Lilly Answers Center
Talk with your doctor or call if you have questions. We’re here to help. Call
1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

Humalog U-200 KwikPen Savings Card
You could pay as little as $25 for your prescription.*† If you have commercial insurance through your employer or independent insurance that is not a government-sponsored plan (for example, Medicaid or Medicare), you may be eligible.
If you already have a savings card, you can click the link below to activate your card and start using your Humalog U-200 KwikPen.
Cards for healthcare providers
*Applies for up to 24 fills prior to program expiration. Save up to $100 per month. This is available for those with insurance who do not receive government reimbursement for their prescriptions.
†See full terms and conditions for eligibility.
For government-sponsored insurance programs
While you are not eligible for the savings card, your co-pay or out-of-pocket costs for Humalog U-200 KwikPen will depend on your insurance plan. Keep in mind that the cost of Humalog U-200 KwikPen is determined by several groups/organizations, including wholesalers and pharmacies.
U-200 Savings Card Support
For medical questions, ask your doctor. For questions about your Humalog U-200 KwikPen, please contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET. Remember that this information doesn’t replace the advice of your doctor. For additional resources and support, click here.
U-200 Savings Card Eligibility Criteria
By using the Humalog U-200 KwikPen savings card ("Card"), you attest that you meet the eligibility criteria and will comply with the Terms and Conditions described below. Offer void where prohibited by law. This offer is invalid for patients without commercial insurance coverage or those whose prescription claims for Humalog U-200 KwikPen are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program. If you live in Massachusetts, the Card expires on the earlier of: (i) the expiration date of this Card (December 31, 2020); (ii) the date an AB rated generic equivalent for Humalog U-200 KwikPen becomes available; or (iii) June 30, 2019, absent a change in Massachusetts state law. Available only in the US and Puerto Rico to residents of the US and Puerto Rico. By accepting this offer, you agree that if you are required to do so under the terms of your insurance coverage for this prescription or are otherwise required to do so by law, you should notify your insurance carrier of your redemption of this Card. This offer is not valid with any other program, discount, incentive, or similar offer involving Humalog U-200 KwikPen. It is prohibited for any person to sell, purchase or trade; or to offer to sell, purchase or trade, or to counterfeit this Card. This offer may be terminated, rescinded, revoked or amended by Lilly USA, LLC at any time without notice. This Card is not health insurance. This Card expires on 12/31/2020.
Offer is invalid for patients without commercial insurance coverage or those whose prescription claims are eligible to be reimbursed, in whole or in part, by any governmental program such as Medicaid, Medicare, etc., or any State assistance program. See full terms and conditions.
Where to inject Humalog U-200
Humalog may be injected under the skin of the stomach area, back of upper arms, upper legs, or buttocks (see diagram). Never inject Humalog into a muscle or vein. Work with your healthcare team to determine the most appropriate injection sites.
Be sure to use a different injection site each time and do not overuse any site.
Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your doctor. Do not inject insulin into a skin area that is red, swollen, or itchy.


Storage and disposal for Humalog U-200 KwikPen
Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.
Humalog should be stored away from light and heat.
Do not use insulin if it has been frozen.
Opened cartridges or prefilled pens should be kept at room temperature.
Prefilled pens and cartridges should be thrown away 28 days after the first use even if there is insulin remaining.
Dispose of needles and pens as directed by your doctor.
Frequently Asked Questions
How long does U-200 KwikPen last once I’ve begun using it?
You will need to discard your Humalog U-200 KwikPen after 28 days in use, even if insulin remains.
Will there be insulin left in my pen when it’s time to discard it?
Humalog U-200 KwikPen is designed to deliver a total of 600 units of insulin. The cartridge contains an additional small amount of insulin that cannot be delivered, so you will see a small amount of insulin left in your pen when it’s time to discard it. Remember: Never withdraw Humalog from the pen using a syringe. It could result in an overdose causing severe low blood sugar, which may put your life in danger.
Because the U-200 KwikPen has double the mealtime insulin, does that mean I have to calculate my dose?
We’ve designed the Humalog U-200 KwikPen so that you don’t have to do any math or calculations to get the correct amount of insulin. You will dial and dose* with the same single-unit measurements as other disposable U-100 mealtime insulin pens.
*Please see Instructions for Use included with the pen.
Where can I get a Humalog U-200 KwikPen savings card?
If you have insurance through your employer or independent insurance that is not a government-sponsored plan (for example, Medicaid or Medicare), ask your doctor for a Humalog U-200 KwikPen savings card. You can also download a new card or activate an existing card here.
Why do I have to activate my Humalog U-200 KwikPen savings card?
Activating your Humalog U-200 KwikPen savings card ensures that your card is ready for use and that you meet the eligibility requirements. It also offers the opportunity for you to sign up to receive continued information about this and other products.
Why am I only getting two pens per box?
Humalog U-200 KwikPen has double the mealtime insulin,* so you do not need as many pens per month.
*As compared with U-100 mealtime insulin pens.
Is Humalog U-200 mealtime insulin available in a vial?
No, it is currently only available in a KwikPen. Remember: Never withdraw Humalog U-200 from the pen using a syringe. It could result in a severe overdose. You should always carry a backup pen.
Must I prime my pen before using it?
Yes, you need to prime your pen. If you do not prime, you may get too much or too little insulin. You will turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and "0" is seen in the dose window. Hold the dose knob in and count to 5 slowly. You should see insulin at the tip of the needle.
Where do I inject U-200 insulin?
Rotate between typical injection sites, such as the abdomen, buttocks, upper legs, or upper arms. Never inject Humalog into a muscle or vein. View the demonstration video for more information.
What should I do if the dose knob is hard to push?
- Pushing the dose knob more slowly will make it easier to inject
- Your needle may be blocked. Put on a new needle and prime the pen
- You may have dust, food, or liquid inside the pen. Throw the pen away and get a new pen
Do not withdraw insulin from the pen with a syringe. If the dose knob is still difficult to push, contact your pharmacy or The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979). View the demonstration video for more information.
What are the potential side effects of U-200?
Low blood sugar is the most common side effect. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site. Please see Important Safety Information for additional side effects. Ask your doctor for more information or for medical advice.
What should I do if I am experiencing any side effects?
If you are experiencing any side effects, please contact your doctor. You may also report side effects to the Food and Drug Administration at 1-800-FDA-1088 or contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).