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Indication for Humalog Brand of Insulins

Humalog® is used to treat people with diabetes for the control of blood sugar. Humalog® Mix75/25(75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50(50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar.

Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog.

Important Safety Information for Humalog Brand of Insulins

What is the most important information I should know about Humalog, Humalog Junior KwikPen, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not share your Humalog, Humalog Junior, Humalog Mix75/25, or Humalog Mix50/50 KwikPens, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL).
  • The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger.
  • Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider.
  • Test your blood sugar levels as your healthcare provider instructs.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.
  • When used in a pump, do not mix or dilute Humalog U-100 with any other insulin or liquid. Do NOT use Humalog U-200, Humalog Mix75/25 or Humalog Mix50/50 in a pump.

Who should not take Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.

Before using Humalog, Humalog Mix75/25, or Humalog Mix50/50, what should I tell my healthcare providers?

  • About all of your medical conditions, including liver, kidney, or heart failure or other heart problems.
  • If you are pregnant, planning to become pregnant, or are breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and nonprescription medicines, vitamins, and herbal supplements.

How should I use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating.
  • Always make sure that you receive the correct type of insulin from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or milky after mixing.
  • Do not mix Humalog U-100 with insulin other than NPH when using a syringe. Do not mix or dilute Humalog U-100 when used in a pump.
  • Never mix Humalog Mix75/25 or Humalog Mix50/50 in the same syringe with other insulin products. Never use Humalog U-200, Humalog Mix75/25 or Humalog Mix50/50 in a pump.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Do not re-use needles. Always use a new needle for each injection. Re-use of needles can cause you to receive the wrong dose of Humalog and result in infection.
  • Do not drive or operate heavy machinery until you know how Humalog affects you. Do not use alcohol while using Humalog.

What are the possible side effects of Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Severe low blood sugar can cause unconsciousness (passing out), seizures, and death. Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much insulin. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 can cause life-threatening low potassium in your blood (hypokalemia), which can cause severe breathing problems, irregular heartbeat, and death.
  • Serious side effects can include swelling of your hands and feet and heart failure when taking certain pills called thiazolidinediones or “TZDs” with Humalog, Humalog Mix75/25, or Humalog Mix50/50. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs, Humalog, Humalog Mix75/25, or Humalog Mix50/50.
  • Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in case of pump failure.
  • The most common side effects of Humalog include low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), itching, and rash. These are not all of the possible side effects. Ask your healthcare provider for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are available by prescription only.

For additional information talk to your healthcare providers and please click to access Humalog Full Prescribing Information, Humalog U-100 Patient Prescribing Information, Humalog U-200 KwikPen Patient Prescribing Information, Humalog Mix75/25 Full Prescribing Information and Patient Prescribing Information, and Humalog Mix50/50 Full Prescribing Information and Patient Prescribing Information.

Please see Instructions for Use included with your pen.

HUMALOG BOI CON ISI 03AUG2017

Humalog®, Humalog® KwikPen® and Humalog® Junior KwikPen® are registered trademarks of Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Humalog® Mix75/25, Humalog® Mix50/50, Humalog® Mix75/25 KwikPen®, and Humalog® Mix50/50™® are trademarks of Eli Lilly and Company and are available by prescription only.

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Indication for Humalog Brand of Insulins

Humalog® is a rapid-acting human insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. Humalog® Mix75/25 (75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50 (50% insulin lispro protamine suspension and 50% insulin lispro injection) are indicated in the treatment of adults with diabetes mellitus for the control of hyperglycemia.

Important Safety Information for Humalog Brand of Insulins

Contraindications

  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 are contraindicated during episodes of hypoglycemia and in patients who are hypersensitive to Humalog or any of its excipients.

Warnings and Precautions

  • Never Share a Humalog KwikPen, Humalog Junior KwikPen, Humalog Mix75/25 KwikPen, or Humalog Mix50/50 KwikPen, Cartridge, Reusable Pen Compatible with Lilly 3 mL Cartridges, or Syringe Between Patients: Humalog, Humalog Mix75/25, and Humalog Mix50/50 KwikPens, cartridges, and reusable pens compatible with Lilly 3 mL cartridges must never be shared between patients, even if the needle is changed. Patients using Humalog, Humalog Mix75/25, or Humalog Mix50/50 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.
  • Changes in Insulin Regimen: Changes may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased.
  • Hypoglycemia: Severe hypoglycemia may be life threatening and can cause seizures or death. Hypoglycemia is the most common adverse reaction of Humalog, Humalog Mix75/25, and Humalog Mix50/50. The patient’s ability to concentrate and react may be impaired as a result of hypoglycemia. Hypoglycemia can happen suddenly and symptoms may vary for each person and may change over time. Early warning symptoms of hypoglycemia may be different or less pronounced under conditions such as long-standing diabetes, diabetic nerve disease, use of medications such as beta-blockers, or in patients who experience recurrent hypoglycemia. These situations may result in severe hypoglycemia and possibly loss of consciousness prior to the patient’s awareness of hypoglycemia.
  • Timing of hypoglycemia usually reflects the time-action profile of administered insulins which may vary in different individuals or at different times in the same individual. Other factors such as changes in food intake, injection site, exercise, and concomitant medications may increase the risk of hypoglycemia.
  • Educate patients to recognize and manage hypoglycemia. In patients at higher risk for hypoglycemia and patients with reduced symptomatic awareness, increased frequency of blood glucose monitoring is recommended. Patients with renal or hepatic impairment may be at higher risk of hypoglycemia.
  • Hypoglycemia Due to Medication Errors: Instruct patients to always check the insulin label before each injection to avoid medication errors.
  • Humalog U-200 should not be transferred from the Humalog KwikPen to a syringe as overdose and severe hypoglycemia can occur.
  • Hypersensitivity Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with Humalog, Humalog Mix75/25, and Humalog Mix50/50. If hypersensitivity reactions occur, discontinue the use of insulin and treat per standard of care until signs and symptoms resolve.
  • Hypokalemia: Hypokalemia may be life threatening. Insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50, cause a shift in potassium from the extracellular to intracellular space possibly leading to hypokalemia, which, if untreated, may result in respiratory paralysis, ventricular arrhythmia, and death. Monitor potassium levels in patients at risk for hypokalemia (eg, patients using potassium-lowering medications or medications sensitive to serum potassium concentrations).
  • Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Thiazolidinediones (TZDs), which are PPAR-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. This may lead to or exacerbate heart failure. Observe patients for signs and symptoms of heart failure and consider discontinuation or dose reduction of the PPAR-gamma agonist.
  • Hyperglycemia and Ketoacidosis Due to Insulin Pump Device Malfunction: Malfunction of the insulin pump device, infusion set, or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis. Patients using subcutaneous insulin infusion pumps must be trained to administer insulin by injection and have alternate insulin therapy available in case of pump failure.

Drug Interactions

  • Some medications may alter glucose metabolism, insulin requirements, and the risk for hypoglycemia or hyperglycemia. Signs of hypoglycemia may be reduced or absent in patients taking anti-adrenergic drugs. Particularly close monitoring may be required.

Adverse Reactions

  • Adverse reactions associated with Humalog include hypoglycemia, hypokalemia, allergic reactions, injection-site reactions, lipodystrophy, pruritus, rash, weight gain, and peripheral edema.

Use in Specific Populations

  • Humalog has not been studied in children with type 1 diabetes less than 3 years of age or in children with type 2 diabetes. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established.

Dosage and Administration

  • Humalog should be given within 15 minutes before or immediately after a meal.
  • Humalog Mix75/25 and Humalog Mix50/50 should be given within 15 minutes before a meal.
  • Humalog U-100 can be administered intravenously under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia. Do NOT administer Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 intravenously.
  • Humalog U-100 for subcutaneous injection should only be mixed with NPH insulin. If Humalog U-100 is mixed with NPH insulin, Humalog should be drawn into the syringe first. Injection should occur immediately after mixing. Do NOT mix Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 in a syringe with any other insulin.
  • Humalog U-100 should not be diluted or mixed when used in an external insulin pump. Change Humalog U-100 in the reservoir at least every 7 days. Change the infusion set and insertion site at least every 3 days. Do NOT use Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 in a subcutaneous insulin infusion pump.
  • Do NOT perform dose conversion when using either the Humalog U-100 or Humalog U-200 KwikPens. The dose window shows the number of insulin units to be delivered and no conversion is needed.

Please click to access Humalog Full Prescribing Information, Humalog Mix75/25 Full Prescribing Information, and Humalog Mix50/50 Full Prescribing Information.

Please see Instructions for Use included with the pen.

HUMALOG BOI HCP ISI 03AUG2017

Humalog®, Humalog® KwikPen® and Humalog® Junior KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Humalog® Mix75/25, Humalog® Mix50/50, Humalog® Mix75/25 KwikPen®, and Humalog® Mix50/50KwikPen® are trademarks of Eli Lilly and Company and are available by prescription only.

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Humalog U-200 KwikPen

Why Humalog® U-200 KwikPen®?

You may have been taking a long-acting insulin for a while now. So why did your doctor prescribe another insulin? Well, it’s to help control the blood sugar spikes that happen naturally when you eat. Everyone gets them, but when you have diabetes you may need extra help controlling them. That’s where Humalog comes in.

Humalog is different than your long-acting insulin. Long-acting insulin helps control your blood sugar throughout the whole day.

Humalog is fast-acting insulin—it helps control the blood sugar spikes that happen naturally when you eat.

Humalog is available in the Humalog U-200 KwikPen, which is portable. And, since it shouldn’t be refrigerated after the first use, you can take it just about anywhere.

Getting Started on Humalog® U-200

Here are a few things to remember when getting started with Humalog U-200:

  • Humalog U-200 is taken 15 minutes before or immediately after a meal
  • Low blood sugar (hypoglycemia) is the most common side effect of Humalog and may be severe and cause unconsciousness, seizures, and death
  • You can treat low blood sugar promptly by eating or drinking something containing sugar (like jelly beans or fruit juice) to get your blood sugar back into a safe range
  • Make sure you understand how many units your doctor wants you to take and with what meals
close-up of dosing knob of Humalog U-100 KwikPen - Easy to deliver the dose, easy to set and see the dose, easy to dial up and back down for dose correction

Easy to deliver the dose

Easy to set and see the dose

Easy to dial up and back down for dose selection

Using Humalog® U-200 KwikPen®

Humalog U-200 KwikPen is a small, lightweight pen that’s prefilled with Humalog U-200 mealtime insulin. It’s portable and can help you inject your mealtime insulin simply and discreetly when you’re away from home.

After you use your pen for the first time, you don’t have to put it back in the refrigerator. Simply drop it into your purse or pocket until you need it again. Remember, always carry an extra pen with you.

LEARN HOW TO USE

Humalog U-200 KwikPen has the same familiar design as the Humalog U-100 KwikPen you may currently be using. When comparing the two, you'll notice some meaningful differences and similarities:

Differences

  • It holds double the mealtime insulin*
  • You will be able to change pens half as often*
  • You will need fewer pens per month*

Similarities

  • It is the same size as Humalog U-100 KwikPen
  • It works just like your Humalog U-100 KwikPen and no dose conversions are necessary
  • Once your KwikPen is opened and used for the first time, it should not be refrigerated and can be used for up to 28 days. After 28 days, the KwikPen should be discarded even if insulin remains.

*As compared with U-100 mealtime insulin pens.

†Once opened, Humalog U-200 KwikPen should be thrown away after 28 days, even if insulin remains.

‡Please see Instructions for Use included with your pen or click here.

How to use Humalog® U-200 KwikPen®

These are not the full instructions. Please see the Instructions for Use included with your pen for full instructions.

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OR CHOOSE A CHAPTER
FROM THE MENU BELOW

  • Introduction

  • Step 1: Preparing Your Humalog U-200 KwikPen

  • Step 2: Priming Your Humalog U-200 KwikPen

  • Step 3: Selecting Your Dose

  • Step 4: Giving Your Injection

  • Step 5: After Your Injection

  • Step 6: Disposing of Your Pens and Needles

  • Step 7: Storing Your Pen

  • Step 8: General Information

  • Step 9: Important Safety Information

Full Prescribing Information and Patient Information

The Lilly Answers Center

Talk with your doctor or call if you have questions. We’re here to help. Call
1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

U200 Savings Card

Humalog U-200 KwikPen Savings Card

You could pay as little as $25 for your prescription.* If you have commercial insurance through your employer or independent insurance that is not a government-sponsored plan (for example, Medicaid or Medicare), you may be eligible.

If you already have a savings card, you can click the link below to activate your card and start using your Humalog U-200 KwikPen.

Have a card?

ACTIVATE YOUR CARD

Need a card?

GET A SAVINGS CARD

Are you currently a resident of the United States or Puerto Rico?

Are you a patient or caregiver 18 years of age or older?

Is your prescription paid in part or full by any government-funded program, including but not limited to Medicaid, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program?

Highlighted red areas on the card below represent information to be entered in the fields.

example-savings-card

Your card is activated

Give your card to the pharmacist to save on your next Humalog prescription.

OH6801041

601341

Are you currently a resident of the United States or Puerto Rico?

Are you a patient or caregiver 18 years of age or older?

Is your prescription paid in part or full by any government-funded program, including but not limited to Medicaid, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program?

Your card is ready.

You may email or print your card. Then, bring it to the pharmacist to save on your next Humalog prescription.

Pay as little as $25 per prescription*

*Applies to each of your first 24 prescriptions. Lilly pays up to $100 per month. Other terms and restrictions apply.

If you have questions, we’re here to help. Call The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

This offer is invalid for patients whose prescription claims are eligible to be reimbursed, in whole or in part, by any governmental program.

RxBin: 601341 RxPCN: OHCP
RxGRP: OH6801041 RxID: [XXXXXXX] SUF: 01

Expiration Date: 12/31/2020

Pharmacist Instructions:

This card must be accompanied by a valid prescription for Humalog U-200 KwikPen. This offer is eligible for patients with commercial insurance who do not receive government reimbursement for their prescriptions. If the patient qualifies per the terms of the offer, submit as a secondary claim to OPUS Health using BIN: 601341 and using the Coordination of Benefits fields with coverage code type 08. One card per patient. By accepting this offer you certify that you understand and agree to comply with the offer terms set forth herein. If you are required to do so under the terms of your third-party payer contracts or as otherwise required by law, you should notify the affected third-party payer of your redemption of this offer. Please return card to patient after claim is processed. Pharmacists with questions, please call OPUS Health at 1-800-364-4767.

Eligibility Requirements:

By using the Humalog U-200 KwikPen savings card ("Card"), you attest that you meet the eligibility criteria and will comply with the Terms and Conditions described below. Offer void where prohibited by law. This offer is invalid for patients without commercial insurance coverage or those whose prescription claims for Humalog U-200 KwikPen are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program. If you live in Massachusetts, the Card expires on the earlier of: (i) the expiration date of this Card (December 31, 2020); (ii) the date an AB rated generic equivalent becomes available; or (iii) June 30, 2019, absent a change in Massachusetts state law. Available only in the US and Puerto Rico to residents of the US and Puerto Rico. By accepting this offer, you agree that if you are required to do so under the terms of your insurance coverage for this prescription or are otherwise required to do so by law, you should notify your insurance carrier of your redemption of this Card. This offer is not valid with any other program, discount, incentive, or similar offer involving Humalog U-200 KwikPen. It is prohibited for any person to sell, purchase or trade; or to offer to sell, purchase or trade, or to counterfeit this Card. This offer may be terminated, rescinded, revoked or amended by Lilly USA, LLC at any time without notice. This Card is not health insurance. This Card expires on 12/31/2020.

PP-DB-US-0400   8/2017 ©Lilly USA, LLC 2017. All rights reserved.

Humalog® and Humalog® KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Cards for healthcare providers

*Applies for up to 24 fills prior to program expiration. Save up to $100 per month. This is available for those with insurance who do not receive government reimbursement for their prescriptions.

†See full terms and conditions for eligibility.


For government-sponsored insurance programs

While you are not eligible for the savings card, your co-pay or out-of-pocket costs for Humalog U-200 KwikPen will depend on your insurance plan. Keep in mind that the cost of Humalog U-200 KwikPen is determined by several groups/organizations, including wholesalers and pharmacies.

U-200 Savings Card Support

For medical questions, ask your doctor. For questions about your Humalog U-200 KwikPen, please contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET. Remember that this information doesn’t replace the advice of your doctor. For additional resources and support, click here.

U-200 Savings Card Eligibility Criteria

By using the Humalog U-200 KwikPen savings card ("Card"), you attest that you meet the eligibility criteria and will comply with the Terms and Conditions described below. Offer void where prohibited by law. This offer is invalid for patients without commercial insurance coverage or those whose prescription claims for Humalog U-200 KwikPen are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program. If you live in Massachusetts, the Card expires on the earlier of: (i) the expiration date of this Card (December 31, 2020); (ii) the date an AB rated generic equivalent for Humalog U-200 KwikPen becomes available; or (iii) June 30, 2019, absent a change in Massachusetts state law. Available only in the US and Puerto Rico to residents of the US and Puerto Rico. By accepting this offer, you agree that if you are required to do so under the terms of your insurance coverage for this prescription or are otherwise required to do so by law, you should notify your insurance carrier of your redemption of this Card. This offer is not valid with any other program, discount, incentive, or similar offer involving Humalog U-200 KwikPen. It is prohibited for any person to sell, purchase or trade; or to offer to sell, purchase or trade, or to counterfeit this Card. This offer may be terminated, rescinded, revoked or amended by Lilly USA, LLC at any time without notice. This Card is not health insurance. This Card expires on 12/31/2020.

Offer is invalid for patients without commercial insurance coverage or those whose prescription claims are eligible to be reimbursed, in whole or in part, by any governmental program such as Medicaid, Medicare, etc., or any State assistance program. See full terms and conditions.

Where to inject Humalog U-200

Humalog may be injected under the skin of the stomach area, back of upper arms, upper legs, or buttocks (see diagram). Never inject Humalog into a muscle or vein. Work with your healthcare team to determine the most appropriate injection sites.

Be sure to use a different injection site each time and do not overuse any site.

Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.

Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your doctor. Do not inject insulin into a skin area that is red, swollen, or itchy.

Front side appropriate injection sites. Stomach, upper legs, back of upper arms.
Back side appropriate injection sites. Back of upper arms, buttocks
 

Storage and disposal for Humalog U-200 KwikPen

Fridge icon

Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.

Fire flame

Humalog should be stored away from light and heat.

Snowflake

Do not use insulin if it has been frozen.

Thermometer

Opened cartridges or prefilled pens should be kept at room temperature.

28 days calendar

Prefilled pens and cartridges should be thrown away 28 days after the first use even if there is insulin remaining.

Toxic Garbage Can

Dispose of needles and pens as directed by your doctor.

Frequently Asked Questions

How long does U-200 KwikPen last once I’ve begun using it?

You will need to discard your Humalog U-200 KwikPen after 28 days in use, even if insulin remains.

Will there be insulin left in my pen when it’s time to discard it?

Humalog U-200 KwikPen is designed to deliver a total of 600 units of insulin. The cartridge contains an additional small amount of insulin that cannot be delivered, so you will see a small amount of insulin left in your pen when it’s time to discard it. Remember: Never withdraw Humalog from the pen using a syringe. It could result in an overdose causing severe low blood sugar, which may put your life in danger.

Because the U-200 KwikPen has double the mealtime insulin, does that mean I have to calculate my dose?

We’ve designed the Humalog U-200 KwikPen so that you don’t have to do any math or calculations to get the correct amount of insulin. You will dial and dose* with the same single-unit measurements as other disposable U-100 mealtime insulin pens.

*Please see Instructions for Use included with the pen.

Where can I get a Humalog U-200 KwikPen savings card?

If you have insurance through your employer or independent insurance that is not a government-sponsored plan (for example, Medicaid or Medicare), ask your doctor for a Humalog U-200 KwikPen savings card. You can also download a new card or activate an existing card here.

Why do I have to activate my Humalog U-200 KwikPen savings card?

Activating your Humalog U-200 KwikPen savings card ensures that your card is ready for use and that you meet the eligibility requirements. It also offers the opportunity for you to sign up to receive continued information about this and other products.

Why am I only getting two pens per box?

Humalog U-200 KwikPen has double the mealtime insulin,* so you do not need as many pens per month.

*As compared with U-100 mealtime insulin pens.

Is Humalog U-200 mealtime insulin available in a vial?

No, it is currently only available in a KwikPen. Remember: Never withdraw Humalog U-200 from the pen using a syringe. It could result in a severe overdose. You should always carry a backup pen.

Must I prime my pen before using it?

Yes, you need to prime your pen. If you do not prime, you may get too much or too little insulin. You will turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and "0" is seen in the dose window. Hold the dose knob in and count to 5 slowly. You should see insulin at the tip of the needle.

Where do I inject U-200 insulin?

Rotate between typical injection sites, such as the abdomen, buttocks, upper legs, or upper arms. Never inject Humalog into a muscle or vein. View the demonstration video for more information.

What should I do if the dose knob is hard to push?

  • Pushing the dose knob more slowly will make it easier to inject
  • Your needle may be blocked. Put on a new needle and prime the pen
  • You may have dust, food, or liquid inside the pen. Throw the pen away and get a new pen

Do not withdraw insulin from the pen with a syringe. If the dose knob is still difficult to push, contact your pharmacy or The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979). View the demonstration video for more information.

What are the potential side effects of U-200?

Low blood sugar is the most common side effect. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site. Please see Important Safety Information for additional side effects. Ask your doctor for more information or for medical advice.

What should I do if I am experiencing any side effects?

If you are experiencing any side effects, please contact your doctor. You may also report side effects to the Food and Drug Administration at 1-800-FDA-1088 or contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

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