You clicked on a page that’s meant for healthcare providers.

This section includes technical information. If you’re a US healthcare provider, click “Continue.” Otherwise, click “Return” to keep reading the main site.

You are now leaving the Humalog.com website

The link you clicked on will take you to a site maintained by a third party, which is solely responsible for its content. Lilly USA, LLC, does not control, influence, or endorse this site, and the opinions, claims, or comments expressed on this site should not be attributed to Lilly USA, LLC. Lilly USA, LLC, is not responsible for the privacy policy of any third-party websites. We encourage you to read the privacy policy of every website you visit.

Click "Continue" to proceed or "Cancel" to return to Humalog.com

Indication for Humalog Brand of Insulins

Humalog is used to treat people with diabetes for the control of blood sugar. Humalog Mix75/25 and Humalog Mix50/50 are used to treat adults with diabetes for the control of high blood sugar.

Important Safety Information for Humalog Brand of Insulins

What is the most important information I should know about Humalog, Humalog Junior KwikPen, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not share your Humalog, Humalog Junior, Humalog Mix75/25, or Humalog Mix50/50 KwikPens, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL).
  • The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger.
  • Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider.
  • Test your blood sugar levels as your healthcare provider instructs.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.
  • When used in a pump, do not mix or dilute Humalog U-100 with any other insulin or liquid. Do NOT use Humalog U-200, Humalog Mix75/25, or Humalog Mix50/50 in a pump.

Who should not take Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.

Before using Humalog, Humalog Mix75/25, or Humalog Mix50/50, what should I tell my healthcare providers?

  • About all of your medical conditions, including liver, kidney, or heart failure or other heart problems.
  • If you are pregnant, planning to become pregnant, or are breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and nonprescription medicines, vitamins, and herbal supplements.

How should I use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating.
  • Always make sure that you receive the correct type of insulin from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or milky after mixing.
  • Do not mix Humalog U-100 with insulin other than NPH when using a syringe. Do not mix or dilute Humalog U-100 when used in a pump.
  • Never mix Humalog Mix75/25 or Humalog Mix50/50 in the same syringe with other insulin products. Never use Humalog U-200, Humalog Mix75/25, or Humalog Mix50/50 in a pump.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Do not re-use needles. Always use a new needle for each injection. Re-use of needles can cause you to receive the wrong dose of Humalog and result in infection.
  • Do not drive or operate heavy machinery until you know how Humalog affects you. Do not use alcohol while using Humalog.

What are the possible side effects of Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Severe low blood sugar can cause unconsciousness (passing out), seizures, and death. Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much insulin. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 can cause life-threatening low potassium in your blood (hypokalemia), which can cause severe breathing problems, irregular heartbeat, and death.
  • Serious side effects can include swelling of your hands and feet and heart failure when taking certain pills called thiazolidinediones or “TZDs” with Humalog, Humalog Mix75/25, or Humalog Mix50/50. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs, Humalog, Humalog Mix75/25, or Humalog Mix50/50.
  • Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in case of pump failure.
  • The most common side effects of Humalog insulins include low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), weight gain, swelling in your hands or feet, itching, and rash. These are not all of the possible side effects. Ask your healthcare provider for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are available by prescription only.

For additional information talk to your healthcare providers and please click to access Humalog Full Prescribing Information, Humalog U-100 Patient Prescribing Information, Humalog U-200 KwikPen Patient Prescribing Information, Humalog Mix75/25 Full Prescribing Information and Patient Prescribing Information, and Humalog Mix50/50 Full Prescribing Information and Patient Prescribing Information.

Please see Instructions for Use included with your pen.

HUMALOG BOI CON ISI 26SEP2018

Humalog®, Humalog® KwikPen® and Humalog® Junior KwikPen® are registered trademarks of Eli Lilly and Company, its subsidiaries, or affiliates.

Humalog® Mix75/25™, Humalog®Mix50/50™, Humalog® Mix75/25™KwikPen®, and Humalog® Mix50/50™® are trademarks of Eli Lilly and Company.

VIEW ALL

Indication for Humalog Brand of Insulins

Humalog is an insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. Humalog Mix75/25 and Humalog Mix50/50 are mixtures of intermediate-acting and rapid-acting insulin analogs indicated to improve glycemic control in patients with diabetes mellitus.

Limitations of Use for Humalog Mix 75/25 and Humalog Mix 50/50: The proportions of rapid-acting and intermediate acting insulins in Humalog Mix 75/25 and Humalog Mix 50/50 are fixed and do not allow for basal versus prandial dose adjustments.

Important Safety Information for Humalog Brand of Insulins

CONTRAINDICATIONS

  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 are contraindicated during episodes of hypoglycemia and in patients who are hypersensitive to Humalog or any of its excipients.

WARNINGS AND PRECAUTIONS

  • Never Share a Humalog KwikPen, Humalog Junior KwikPen, Humalog Mix75/25 KwikPen, or Humalog Mix50/50 KwikPen, Cartridge, Reusable Pen Compatible with Lilly 3 mL Cartridges, or Syringe Between Patients: Humalog, Humalog Mix75/25, and Humalog Mix50/50 KwikPens, cartridges, and reusable pens compatible with Lilly 3 mL cartridges must never be shared between patients, even if the needle is changed. Patients using Humalog, Humalog Mix75/25, or Humalog Mix50/50 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.
  • Changes in Insulin Regimen: Changes may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased.
  • Hypoglycemia: Severe hypoglycemia may be life threatening and can cause seizures or death. Hypoglycemia is the most common adverse reaction of Humalog, Humalog Mix75/25, and Humalog Mix50/50. The patient’s ability to concentrate and react may be impaired as a result of hypoglycemia. Hypoglycemia can happen suddenly and symptoms may vary for each person and may change over time. Early warning symptoms of hypoglycemia may be different or less pronounced under conditions such as long-standing diabetes, diabetic nerve disease, use of medications such as beta-blockers, or in patients who experience recurrent hypoglycemia. These situations may result in severe hypoglycemia and possibly loss of consciousness prior to the patient’s awareness of hypoglycemia.

    Timing of hypoglycemia usually reflects the time-action profile of administered insulins which may vary in different individuals or at different times in the same individual. Other factors such as changes in food intake, injection site, exercise, and concomitant medications may increase the risk of hypoglycemia.

    Educate patients to recognize and manage hypoglycemia. In patients at higher risk for hypoglycemia and patients with reduced symptomatic awareness, increased frequency of blood glucose monitoring is recommended. Patients with renal or hepatic impairment may be at higher risk of hypoglycemia.
  • Hypoglycemia Due to Medication Errors: Instruct patients to always check the insulin label before each injection to avoid medication errors.

    Humalog U-200 should not be transferred from the Humalog KwikPen to a syringe as overdose and severe hypoglycemia can occur.
  • Hypersensitivity Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with Humalog, Humalog Mix75/25, and Humalog Mix50/50. If hypersensitivity reactions occur, discontinue the use of insulin and treat per standard of care until signs and symptoms resolve.
  • Hypokalemia: Hypokalemia may be life threatening. Insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50, cause a shift in potassium from the extracellular to intracellular space possibly leading to hypokalemia, which, if untreated, may result in respiratory paralysis, ventricular arrhythmia, and death. Monitor potassium levels in patients at risk for hypokalemia (eg, patients using potassium-lowering medications or medications sensitive to serum potassium concentrations).
  • Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Thiazolidinediones (TZDs), which are PPAR-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. This may lead to or exacerbate heart failure. Observe patients for signs and symptoms of heart failure and consider discontinuation or dose reduction of the PPAR-gamma agonist.
  • Hyperglycemia and Ketoacidosis Due to Insulin Pump Device Malfunction: Malfunction of the insulin pump device, infusion set, or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis. Patients using subcutaneous insulin infusion pumps must be trained to administer insulin by injection and have alternate insulin therapy available in case of pump failure.

DRUG INTERACTIONS: Some medications may alter glucose metabolism, insulin requirements, and the risk for hypoglycemia or hyperglycemia. Signs of hypoglycemia may be reduced or absent in patients taking anti-adrenergic drugs. Particularly close monitoring may be required.

ADVERSE REACTIONS: Adverse reactions associated with Humalog include hypoglycemia, hypokalemia, allergic reactions, injection-site reactions, lipodystrophy, pruritus, rash, weight gain, and peripheral edema.

USE IN SPECIFIC POPULATIONS: Humalog has not been studied in children with type 1 diabetes less than 3 years of age or in children with type 2 diabetes. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established.

Please click to access Humalog Full Prescribing Information, Humalog Mix75/25 Full Prescribing Information, and Humalog Mix50/50 Full Prescribing Information.

Please see Instructions for Use included with the pen.

HUMALOG BOI HCP ISI 26SEP2018

Humalog®, Humalog® KwikPen® and Humalog® Junior KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Humalog® Mix75/25™, Humalog®Mix50/50™, Humalog® Mix75/25™KwikPen®, and Humalog®Mix50/50™KwikPen® are trademarks of Eli Lilly and Company and are available by prescription only.

VIEW ALL

Indicación de la marca de insulinas Humalog

HUMALOG es un análogo de la insulina humana de acción rápida indicado para mejorar el control glucémico en adultos y niños con diabetes mellitus.

Información Importante de Seguridad

¿Qué es lo más importante que debo saber acerca de Humalog?

  • No compartas tu Humalog KwikPen, Humalog Junior KwikPen, los cartuchos, la pluma reusable compatible con los cartuchos Lilly de 3 mL, o las jeringas con otras personas, aunque hayas cambiado la aguja, ya que podrías transmitir o contraer una infección grave.
  • No cambies la insulina que usas sin consultar con tu médico. Los cambios pueden hacerte más susceptible a experimentar niveles bajos o altos de azúcar en la sangre. Cualquier cambio debe hacerse con mucha precaución y solo bajo supervisión médica.
  • Hazte las pruebas de nivel de azúcar en la sangre según lo indique el médico.
  • Puede que tengas que cambiar la dosis de insulina debido a una enfermedad, estrés, otros medicamentos que tomas o te aplicas, cambios en la dieta o cambios en la actividad física o ejercicios.
  • Cuando utilices la insulina en una bomba, no mezcles ni diluyas Humalog con ninguna otra insulina o líquido.

¿Quién no debe utilizar Humalog?

  • No utilices Humalog si tu nivel de azúcar en la sangre es demasiado bajo (hipoglucemia) o si eres alérgico a la insulina lispro o a cualquiera de los ingredientes de Humalog.

¿Qué información debo suministrar a mis médicos antes de comenzar a usar Humalog?

  • Todo sobre tus condiciones médicas, incluyendo deficiencias hepáticas, renales o cardíacas, u otros problemas cardíacos.
  • Si estás embarazada –o planeas estarlo– o estás lactando.
  • Todos los medicamentos con receta, (especialmente los comúnmente denominados TZD [tiazolidinedionas]) y todas las vitaminas y suplementos herbales sin receta que tomes.

¿Cómo debo utilizar Humalog?

  • Humalog es una insulina de acción rápida. Aplícate Humalog quince minutos antes de las comidas o inmediatamente después de comer.
  • Siempre verifica que la farmacia te haya entregado el tipo correcto de Humalog.
  • No uses Humalog si se ve turbia, tiene color, partículas sólidas o grumos.
  • Inyecta Humalog debajo de la piel (subcutáneamente). Nunca te la inyectes en una vena o un músculo. Cambia (rota) la zona en la que te inyectas con cada dosis. Asegúrate de inyectarte la insulina y la dosis correctas.
  • No vuelvas a utilizar las agujas. Usa siempre una aguja nueva para cada inyección. Volver a utilizar una aguja puede hacer que recibas la dosis incorrecta de Humalog y provocarte una infección.
  • No conduzcas ni operes maquinaria pesada hasta que sepas cómo te afecta Humalog. No consumas alcohol mientras utilizas Humalog.

¿Cuáles son los posibles efectos secundarios de Humalog?

  • Si el bajo nivel de azúcar en la sangre es grave, puede causar pérdida del conocimiento (desmayo), convulsiones y muerte. Un bajo nivel de azúcar en la sangre es el efecto secundario más común. Existen muchos factores que provocan la disminución del nivel de azúcar en la sangre, incluyendo recibir demasiado Humalog. Es importante tratarlo rápidamente. Puedes tratar un nivel de azúcar en la sangre de leve a moderadamente bajo tomando o comiendo de inmediato algo que contenga azúcar. Los síntomas podrían ser diferentes de una persona a otra. Habla con tu médico sobre los síntomas del bajo nivel de azúcar en la sangre y cómo tratarlos.
  • Pueden ocurrir reacciones alérgicas graves (reacciones en todo el cuerpo) que podrían poner tu vida en peligro. Solicita asistencia médica de inmediato si experimentas una erupción en todo el cuerpo, tienes dificultades para respirar, seintes taquicardia o comienzas a sudar.
  • Humalog puede provocar un nivel bajo de potasio en sangre (hipocalemia) que podría poner tu vida en peligro y causar graves problemas de respiración, latidos cardíacos irregulares y la muerte.
  • Los efectos secundarios graves pueden incluir hinchazón de las manos y pies e insuficiencia cardíaca cuando se toman ciertas píldoras llamadas tiazolidinedionas o “TZD” junto con Humalog. Algunas personas pueden experimentar estos síntomas aunque no hayan tenido problemas cardíacos anteriormente. Infórmale a tu médico si tienes dificultad para respirar, hinchazón de tobillos o pies, o un repentino aumento de peso, los cuales pueden ser síntomas de insuficiencia cardíaca. Es probable que tu médico deba ajustar o interrumpir el tratamiento con TZD o Humalog.
  • Una falla en tu bomba de insulina o dispositivo de infusión de insulina, o el deterioro de la insulina en la bomba, pueden provocar hiperglucemia y cetoacidosis. Ten siempre a mano un método alternativo de administración de insulina en caso de que la bomba falle.
  • Los efectos secundarios más comunes de Humalog incluyen bajos niveles de azúcar en la sangre, reacciones alérgicas, lo que incluye reacciones en la zona en la que se aplica la inyección, engrosamiento de la piel u orificios en la zona de aplicación de la inyección (lipodistrofia), picazón y salpullido. Estos no son todos los efectos secundarios posibles. Pídele a tu médico más información o consejos sobre los efectos secundarios.

Te recomendamos que informes los efectos secundarios negativos de los medicamentos recetados a la FDA. Visita www.fda.gov/medwatch o llame al 1-800-FDA-1088.

Humalog se vende solo con receta.

HI CON ISI 06JUN2017

Humalog® y Humalog® KwikPen® son marcas registradas de propiedad de, o con licencia de Eli Lilly and Company, sus subsidiarias o afiliadas.

Para más información, habla con tus médicos y haz clic para acceder a la Prescripción Completa e Información de Prescripción para el Paciente.

Lee las Instrucciones de Uso incluidas en la Humalog KwikPen

VIEW ALL
image of Humalog Mix75/25 KwikPen and Humalog Mix50/50 KwikPen

Why
Humalog®
Mixes?

Humalog® Mix75/25 and Humalog® Mix50/50 are combinations of fast- and longer-acting insulins that work together to help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.

Humalog mixes start working faster than other insulins that contain regular human insulin.

It's important to take Humalog mixes within 15 minutes before eating a meal to help prevent low blood sugar.

Low blood sugar (hypoglycemia) is the most common side effect of Humalog mixes that may be severe and cause seizures and death.

Make sure you understand how many units your doctor wants you to take and with what meals.

close-up of Humalog Mix75/25 KwikPen dosing window - Easy to deliver the dose, easy to set and see the dose, easy to dial up and back down for dose correction

Easy to deliver the dose

Easy to set and see the dose

Easy to dial up and back down for dose selection

Using Humalog Premixed Insulin KwikPen

Humalog® KwikPen® is a small, lightweight pen that’s prefilled with mealtime insulin. Plus, since it shouldn't be refrigerated after the first use, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it’s the size of a marker. It’s a good idea to always carry an extra pen.

Once you start using Humalog KwikPen, it should be stored at room temperature, below 86°F (30°C), and must be used within 10 days or be discarded, even if it still contains Humalog.

How to use Humalog® Mix75/25 KwikPen® or Humalog® Mix50/50 KwikPen®

Humalog Mix75/25

Full Prescribing Information, Patient Information, and Instructions for Use

Humalog Mix50/50

Full Prescribing Information, Patient Information, and Instructions for Use

The Lilly Answers Center

Talk with your doctor or call if you have questions. We’re here to help. Call
1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

Where to inject Humalog Mix75/25 and Humalog Mix50/50

Humalog Mix75/25 and Humalog Mix50/50 may be injected under the skin of the stomach area, back of upper arms, upper legs, or buttocks (see diagram). Never inject Humalog mixes into a muscle or vein. Work with your doctor to determine the most appropriate injection sites.

Be sure to use a different injection site each time and do not overuse any site.

Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.

Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your doctor. Do not inject insulin into a skin area that is red, swollen, or itchy.

Front side appropriate injection sites. Stomach, upper legs, back of upper arms.
Back side appropriate injection sites. Back of upper arms, buttocks
 

Storage and disposal for Humalog KwikPen

Fridge icon

Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.

Fire flame

Humalog should be stored away from light and heat.

Snowflake

Do not use insulin if it has been frozen.

Thermometer

Opened cartridges or prefilled pens should be kept at room temperature.

10 days calendar

Prefilled pens should be thrown away 10 days after the first use even if there is insulin remaining.

Toxic Garbage Can

Dispose of needles and pens as directed by your doctor.

Other ways to take Humalog mixes

There are other ways to take Humalog mixes besides the KwikPen. Both premixed insulins are available in a vial. You and your doctor should discuss which option would be best for you.

Click here to learn how to use a vial and syringe.

vials of Humalog Mixes

Storage and disposal for vials

Icon: Refrigerator

Store all unopened (unused) vials in the original carton in a refrigerator. Do not freeze.

Icon: Refrigerator and vial

Unopened, refrigerated vials can be kept until expiration date.

Icon: Thermometer

After first use (opened), store vial in the refrigerator (not the freezer) or, if necessary, at room temperature below 86°F (30°C). Do not use if vial has been frozen.

Icon: 28 days calendar

Throw away open vials 28 days after first use, even if there is insulin left in the vial.

Icon: Toxic Garbage Can

Do not use after the expiration date printed on the carton and label.

Icon: Avoid Sunlight

Protect from direct heat and light.

Safely dispose of needles and syringes as directed by your doctor.

For full storage and disposal information, please see the Patient Information leaflet that comes with your insulin.

Disposal of needles and syringes

Icon: Toxic Garbage Can

Place all needles and syringes in a sharps disposal container immediately after they have been used.

  • Never place loose needles in any trash can or recycling bin and never flush them down the toilet
  • Carry a small, travel-size sharps disposal container when leaving home
Icon: Do not reuse sharps containers

Dispose of the sharps container according to community guidelines.

  • Do not reuse sharps containers

For information about disposal of syringes and needles, visit the US Food and Drug Administration website at fda.gov/safesharpsdisposal or call 1-888-INFO-FDA (1-888-463-6332).

Frequently Asked Questions

How long do Humalog Mix75/25 and Humalog Mix50/50 last once I’ve begun using them?

You will need to discard your Humalog Mix75/25 KwikPen and Humalog Mix50/50 KwikPen after 10 days in use, even if insulin remains.

Will there be insulin left in my pen when it’s time to discard it?

KwikPen is designed to deliver a total of 300 units of insulin. The cartridge contains an additional small amount of insulin that cannot be delivered, so you will see a small amount of insulin left in your pen when it's time to discard it. Remember: Never withdraw Humalog from the pen using a syringe. It could result in an overdose causing severe low blood sugar, which may put your life in danger.

Must I prime my pen before using it?

Yes, you need to prime your pen. If you do not prime, you may get too much or too little insulin. You will turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and zero is seen in the dose window. Hold the dose knob in and count to 5 slowly. You should see insulin at the tip of the needle.

Where do I inject Humalog Mix75/25 or Humalog Mix50/50 insulin?

Rotate between typical injection sites, such as the abdomen, buttocks, upper legs, or upper arms. View the Instructions for Use for more information.

What should I do if the dose knob is hard to push?

  • Pushing the dose knob more slowly will make it easier to inject
  • Your needle may be blocked. Put on a new needle and prime the pen
  • You may have dust, food, or liquid inside the pen. Throw the pen away and get a new pen

Do not withdraw insulin from the pen with a syringe. If the dose knob is still difficult to push, contact your pharmacy or The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979). View the Instructions for Use for Humalog Mix75/25 KwikPen or Humalog Mix50/50 KwikPen.

What are the potential side effects for Humalog Mix75/25 or Humalog Mix50/50?

Low blood sugar is the most common side effect. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site. Please see Important Safety Information for additional side effects. Ask your doctor for more information or for medical advice.

What should I do if I am experiencing any side effects?

If you are experiencing any side effects, please contact your doctor. You may also report side effects to the Food and Drug Administration at 1-800-FDA-1088 or contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

You clicked on a page that’s meant for healthcare providers.

This section includes technical information. If you’re a US healthcare provider, click “Continue.” Otherwise, click “Return” to keep reading the main site.

You are now leaving the Humalog.com website

The link you clicked on will take you to a site maintained by a third party, which is solely responsible for its content. Lilly USA, LLC, does not control, influence, or endorse this site, and the opinions, claims, or comments expressed on this site should not be attributed to Lilly USA, LLC. Lilly USA, LLC, is not responsible for the privacy policy of any third-party websites. We encourage you to read the privacy policy of every website you visit.

Click "Continue" to proceed or "Cancel" to return to Humalog.com