Learn about our convenient insulin pens, download step-by-step guides, and watch our injection tutorials.
How to Take Mixture Insulin
Humalog Mix75/25 and Humalog Mix50/50 are mixture insulins that must be injected into your body. Because they contain rapid-acting
insulin, their "onset of action" is very quick.
You should take your dose of mixture insulin within 15 minutes before you eat.
How often you need to take your insulin
Treatment plans are different for different people. Some people may be able to control their blood sugar with only two injections per day (generally at breakfast and supper). Others may need to take their insulin three or four times a day. Your doctor will recommend the dosing schedule that he or she believes is best for you.
Choices and the "ouch" factor
There's more than one way to take Humalog Mixture insulins, from a traditional syringe to the Prefilled Pen. One of the first questions that people ask when starting insulin is, "Will it hurt?" Today, insulin needles are short and tiny, so they cause minimal discomfort. Your doctor or diabetes educator will show you how to give yourself an injection. Also, be sure to ask your healthcare team about all your options for insulin delivery devices.
Choosing the site for an insulin injection
Knowing exactly where on your body you should give your injection(s) each day is very important. In general, you can give an injection anywhere there is a layer of fat under the skin. The chart below shows sites for your insulin injections in the purple and white grid areas. Each square is a place to give yourself an injection. You may need help from a family member to give injections in some of the sites.

Rotating sites
For your insulin to work best, it's important to use a different location for each injection. This is called "site rotation," and involves following a regular pattern as you move from site to site. If you take more than one injection each day, use a different area for each injection. Different people use different patterns, but the intent should always be to use all of the areas and the sites. When you do this, no one site will be used too often. Overusing a site can cause tissue changes that lower or change insulin absorption.
Giving an injection is simple, but it does take practice. Once you deal with any worries, a little practice will make you an expert. If you are having trouble in the beginning, be sure to talk to your doctor or diabetes educator. Also, check out our injection tips and patient education materials for more helpful information and detailed instructions for taking injections.
Humalog Mix75/25 and Humalog Mix50/50 are available by prescription only. See Humalog Mix75/25 and Humalog Mix50/50 Patient Information for important facts about these products.
Important Safety Information
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with a longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.
Humalog insulins are contraindicated during episodes of hypoglycemia and in patients sensitive to Humalog or one of its excipients. The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no clinical studies of the use of Humalog insulins in pregnancy or nursing mothers.
Potential side effects associated with the use of all insulins include low blood sugar, weight gain, low blood potassium, changes in fat tissue at the site of injection, and allergic reactions, both general and local. Humalog Mix75/25 and Humalog Mix50/50 should not be mixed with another insulin. Starting or changing insulin therapy should be done cautiously and only under medical supervision.
Humalog insulins are available by prescription only. See the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Product Information for important facts about these products.
Humalog is a registered trademark of Eli Lilly and Company. Humalog Mix75/25 and Humalog Mix50/50 are trademarks of Eli Lilly and Company.
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with a longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.
Humalog insulins are contraindicated during episodes of hypoglycemia and in patients sensitive to Humalog or one of its excipients. The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no clinical studies of the use of Humalog insulins in pregnancy or nursing mothers.
Potential side effects associated with the use of all insulins include low blood sugar, weight gain, low blood potassium, changes in fat tissue at the site of injection, and allergic reactions, both general and local. Humalog Mix75/25 and Humalog Mix50/50 should not be mixed with another insulin. Starting or changing insulin therapy should be done cautiously and only under medical supervision.
Humalog insulins are available by prescription only. See the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Product Information for important facts about these products.
Humalog is a registered trademark of Eli Lilly and Company. Humalog Mix75/25 and Humalog Mix50/50 are trademarks of Eli Lilly and Company.























