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Indication for Humalog Brand of Insulins

Humalog® is used to treat people with diabetes for the control of blood sugar. Humalog® Mix75/25 (75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50 (50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar.

Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog.

Important Safety Information for Humalog Brand of Insulins

What is the most important information I should know about Humalog, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not share your Humalog, Humalog Mix75/25, or Humalog Mix50/50 KwikPen, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL).
  • The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger.
  • Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider.
  • Test your blood sugar levels as your healthcare provider instructs.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.
  • When used in a pump, do not mix or dilute Humalog U-100 with any other insulin or liquid. Do NOT use Humalog U-200, Humalog Mix75/25 or Humalog Mix50/50 in a pump.

Who should not take Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.

Before using Humalog, Humalog Mix75/25, or Humalog Mix50/50, what should I tell my healthcare providers?

  • About all of your medical conditions, including liver, kidney, or heart failure or other heart problems.
  • If you are pregnant, planning to become pregnant, or are breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and nonprescription medicines, vitamins, and herbal supplements.

How should I use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating.
  • Always make sure that you receive the correct type of insulin from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or milky after mixing.
  • Do not mix Humalog U-100 with insulin other than NPH when using a syringe. Do not mix or dilute Humalog U-100 when used in a pump.
  • Never mix Humalog Mix75/25 or Humalog Mix50/50 in the same syringe with other insulin products. Never use Humalog U-200, Humalog Mix75/25 or Humalog Mix50/50 in a pump.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Do not re-use needles. Always use a new needle for each injection. Re-use of needles can cause you to receive the wrong dose of Humalog and result in infection.
  • Do not drive or operate heavy machinery until you know how Humalog affects you. Do not use alcohol while using Humalog.

What are the possible side effects of Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Severe low blood sugar can cause unconsciousness (passing out), seizures, and death. Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much insulin. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 can cause life-threatening low potassium in your blood (hypokalemia), which can cause severe breathing problems, irregular heartbeat, and death.
  • Serious side effects can include swelling of your hands and feet and heart failure when taking certain pills called thiazolidinediones or “TZDs” with Humalog, Humalog Mix75/25, or Humalog Mix50/50. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs, Humalog, Humalog Mix75/25, or Humalog Mix50/50.
  • Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in case of pump failure.
  • The most common side effects of Humalog include low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), itching, and rash. These are not all of the possible side effects. Ask your healthcare provider for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit fda.gov/medwatch or call 1-800-FDA-1088.

For additional information talk to your healthcare providers and please click to access Humalog Full Prescribing Information, Humalog U-100 Patient Prescribing Information, Humalog U-200 KwikPen Patient Prescribing Information, Humalog Mix75/25 Full Prescribing Information and Patient Prescribing Information, and Humalog Mix50/50 Full Prescribing Information and Patient Prescribing Information.

Please see Instructions for Use included with your pen.

HI U200 BOI CON ISI 26MAY2015

Humalog® and Humalog® KwikPen® are registered trademarks of Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Humalog® Mix75/25, Humalog® Mix50/50, Humalog® Mix75/25 KwikPen®, and Humalog® Mix50/50 KwikPen® are trademarks of Eli Lilly and Company and are available by prescription only.

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Indication for Humalog Brand of Insulins

Humalog® is a rapid-acting human insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. Humalog® Mix75/25 (75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50 (50% insulin lispro protamine suspension and 50% insulin lispro injection) are indicated in the treatment of adults with diabetes mellitus for the control of hyperglycemia.

Important Safety Information for Humalog Brand of Insulins

Contraindications

  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 are contraindicated during episodes of hypoglycemia and in patients who are hypersensitive to Humalog or any of its excipients.

Warnings and Precautions

  • Never Share a Humalog KwikPen, Humalog Mix75/25 KwikPen, or Humalog Mix50/50 KwikPen, Cartridge, Reusable Pen Compatible with Lilly 3 mL Cartridges, or Syringe Between Patients: Humalog, Humalog Mix75/25, and Humalog Mix50/50 KwikPens, cartridges, and reusable pens compatible with Lilly 3 mL cartridges must never be shared between patients, even if the needle is changed. Patients using Humalog, Humalog Mix75/25, or Humalog Mix50/50 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.
  • Changes in Insulin Regimen: Changes may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased.
  • Hypoglycemia: Severe hypoglycemia may be life threatening and can cause seizures or death. Hypoglycemia is the most common adverse reaction of Humalog, Humalog Mix75/25, and Humalog Mix50/50. The patient’s ability to concentrate and react may be impaired as a result of hypoglycemia. Hypoglycemia can happen suddenly and symptoms may vary for each person and may change over time. Early warning symptoms of hypoglycemia may be different or less pronounced under conditions such as long-standing diabetes, diabetic nerve disease, use of medications such as beta-blockers, or in patients who experience recurrent hypoglycemia. These situations may result in severe hypoglycemia and possibly loss of consciousness prior to the patient’s awareness of hypoglycemia.
  • Timing of hypoglycemia usually reflects the time-action profile of administered insulins which may vary in different individuals or at different times in the same individual. Other factors such as changes in food intake, injection site, exercise, and concomitant medications may increase the risk of hypoglycemia.
  • Educate patients to recognize and manage hypoglycemia. In patients at higher risk for hypoglycemia and patients with reduced symptomatic awareness, increased frequency of blood glucose monitoring is recommended. Patients with renal or hepatic impairment may be at higher risk of hypoglycemia.
  • Hypoglycemia Due to Medication Errors: Instruct patients to always check the insulin label before each injection to avoid medication errors.
  • Humalog U-200 should not be transferred from the Humalog KwikPen to a syringe as overdose and severe hypoglycemia can occur.
  • Hypersensitivity Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with Humalog, Humalog Mix75/25, and Humalog Mix50/50. If hypersensitivity reactions occur, discontinue the use of insulin and treat per standard of care until signs and symptoms resolve.
  • Hypokalemia: Hypokalemia may be life threatening. Insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50, cause a shift in potassium from the extracellular to intracellular space possibly leading to hypokalemia, which, if untreated, may result in respiratory paralysis, ventricular arrhythmia, and death. Monitor potassium levels in patients at risk for hypokalemia (eg, patients using potassium-lowering medications or medications sensitive to serum potassium concentrations).
  • Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Thiazolidinediones (TZDs), which are PPAR-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. This may lead to or exacerbate heart failure. Observe patients for signs and symptoms of heart failure and consider discontinuation or dose reduction of the PPAR-gamma agonist.
  • Hyperglycemia and Ketoacidosis Due to Insulin Pump Device Malfunction: Malfunction of the insulin pump device, infusion set, or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis. Patients using subcutaneous insulin infusion pumps must be trained to administer insulin by injection and have alternate insulin therapy available in case of pump failure.

Drug Interactions

  • Some medications may alter glucose metabolism, insulin requirements, and the risk for hypoglycemia or hyperglycemia. Signs of hypoglycemia may be reduced or absent in patients taking anti-adrenergic drugs. Particularly close monitoring may be required.

Adverse Reactions

  • Adverse reactions associated with Humalog include hypoglycemia, hypokalemia, allergic reactions, injection-site reactions, lipodystrophy, pruritus, rash, weight gain, and peripheral edema.

Use in Specific Populations

  • Humalog has not been studied in children with type 1 diabetes less than 3 years of age or in children with type 2 diabetes. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established.

Dosage and Administration

  • Humalog should be given within 15 minutes before or immediately after a meal.
  • Humalog Mix75/25 and Humalog Mix50/50 should be given within 15 minutes before a meal.
  • Humalog U-100 can be administered intravenously under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia. Do NOT administer Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 intravenously.
  • Humalog U-100 for subcutaneous injection should only be mixed with NPH insulin. If Humalog U-100 is mixed with NPH insulin, Humalog should be drawn into the syringe first. Injection should occur immediately after mixing. Do NOT mix Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 in a syringe with any other insulin.
  • Humalog U-100 should not be diluted or mixed when used in an external insulin pump. Change Humalog U-100 in the reservoir at least every 7 days. Change the infusion set and insertion site at least every 3 days. Do NOT use Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 in a subcutaneous insulin infusion pump.
  • Do NOT perform dose conversion when using either the Humalog U-100 or Humalog U-200 KwikPens. The dose window shows the number of insulin units to be delivered and no conversion is needed.

Please click to access Humalog Full Prescribing Information, Humalog Mix75/25 Full Prescribing Information, and Humalog Mix50/50 Full Prescribing Information.

Please see Instructions for Use included with the pen.

HI BOI U200 HCP ISI 26MAY2015

Humalog® and Humalog® KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Humalog® Mix75/25, Humalog® Mix50/50, Humalog® Mix75/25 KwikPen®, and Humalog® Mix50/50 KwikPen® are trademarks of Eli Lilly and Company and are available by prescription only.

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WATCH THIS VIDEO
FOR
STEP-BY-STEP
INSTRUCTIONS

*As compared with U-100 mealtime insulin pens.

About Humalog® U-200 KwikPen®

If you go through 3 or more mealtime insulin pens each month, Humalog U-200 KwikPen might be right for you. Humalog U-200 KwikPen is the first and only pen that holds double the mealtime insulin as U-100 pens, which means you may be able to change your plans without changing pens.* Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger.

*As with other pens, you should always carry an extra pen.

U-200 KwikPen LOGO

Humalog U-200 KwikPen has the same familiar design as the Humalog U-100 KwikPen you may currently be using. When comparing the two, you'll notice some meaningful differences and similarities:

Differences

  • It holds double the mealtime insulin*
  • You will be able to change pens half as often*
  • You will need fewer pens per month*

Similarities

  • It is the same size as Humalog U-100 KwikPen
  • It works just like your Humalog U-100 KwikPen and no dose conversions are necessary
  • Once your KwikPen is opened and used for the first time, it should not be refrigerated and can be used for up to 28 days. After 28 days, the KwikPen should be discarded even if insulin remains.

*As compared with U-100 mealtime insulin pens.

†Once opened, Humalog U-200 KwikPen should be thrown away after 28 days, even if insulin remains.

‡Please see Instructions for Use included with your pen or click here.

U200 Savings Card illustration of savings card “Activate and Save!”

Humalog U-200 KwikPen Savings Card

You could pay as little as $25 for your prescription.*† If you have commercial insurance through your employer or independent insurance that is not a government-sponsored plan (for example, Medicaid or Medicare), you may be eligible.

If you already have a savings card, you can click the link below to activate your card and start using your Humalog U-200 KwikPen.

Have a card?

ACTIVATE YOUR CARD

Need a card?

GET A SAVINGS CARD

Are you currently a resident of the United States or Puerto Rico?

Are you a patient or caregiver 18 years of age or older?

Is your prescription paid in part or full by any government-funded program, including but not limited to Medicaid, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program?

Highlighted red areas on the card below represent information to be entered in the fields to the right.

example-savings-card

Your card is activated

Give your card to the pharmacist to save on your next Humalog prescription.

OH6801041

601341

Are you currently a resident of the United States or Puerto Rico?

Are you a patient or caregiver 18 years of age or older?

Is your prescription paid in part or full by any government-funded program, including but not limited to Medicaid, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program?

Your card is ready.

You may email or print your card. Then, bring it to the pharmacist to save on your next Humalog prescription.

Pay as little as $25 per prescription*

*Applies to each of your first 24 prescriptions. Lilly pays up to $100 per month. Other terms and restrictions apply.

If you have questions, we’re here to help. Call The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

This offer is invalid for patients whose prescription claims are eligible to be reimbursed, in whole or in part, by any governmental program.

RxBin: 601341 RxPCN: OHCP
RxGRP: OH6801041 RxID: [XXXXXXX] SUF: 01

Expiration Date: 12/31/2019

Pharmacist Instructions:

This card must be accompanied by a valid prescription for Humalog U-200 KwikPen. This offer is eligible for patients with commercial insurance who do not receive government reimbursement for their prescriptions. If the patient qualifies per the terms of the offer, submit as a secondary claim to OPUS Health using BIN: 601341 and using the Coordination of Benefits fields with coverage code type 08. One card per patient. By accepting this offer you certify that you understand and agree to comply with the offer terms set forth herein. If you are required to do so under the terms of your third-party payer contracts or as otherwise required by law, you should notify the affected third-party payer of your redemption of this offer. Please return card to patient after claim is processed. Pharmacists with questions, please call OPUS Health at 1-800-364-4767.

Eligibility Requirements:

By using the Humalog U-200 KwikPen savings card ("Card"), you attest that you meet the eligibility criteria and will comply with the Terms and Conditions described below. Offer void where prohibited by law. This offer is invalid for patients without commercial insurance coverage or those whose prescription claims for Humalog U-200 KwikPen are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program. If you live in Massachusetts, the Card expires on the earlier of: (i) the expiration date of this Card (December 31, 2019); (ii) the date an AB rated generic equivalent becomes available; or (iii) June 30, 2017, absent a change in Massachusetts state law. Available only in the US and Puerto Rico to residents of the US and Puerto Rico. By accepting this offer, you agree that if you are required to do so under the terms of your insurance coverage for this prescription or are otherwise required to do so by law, you should notify your insurance carrier of your redemption of this Card. This offer is not valid with any other program, discount, incentive, or similar offer involving Humalog U-200 KwikPen. It is prohibited for any person to sell, purchase or trade; or to offer to sell, purchase or trade, or to counterfeit this Card. This offer may be terminated, rescinded, revoked or amended by Lilly USA, LLC at any time without notice. This Card is not health insurance. This Card expires on 12/31/2019.

PP-HI-US-0807 10/2016 ©Lilly USA, LLC 2016. All rights reserved.

Humalog® and Humalog® KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Cards for healthcare providers

*Applies for up to 24 fills prior to program expiration. Save up to $100 per month. This is available for those with insurance who do not receive government reimbursement for their prescriptions.

†See full terms and conditions for eligibility.

For government-sponsored insurance programs:

While you are not eligible for the savings card, your co-pay or out-of-pocket costs for Humalog U-200 KwikPen will depend on your insurance plan. Keep in mind that the cost of Humalog U-200 KwikPen is determined by several groups/organizations, including wholesalers and pharmacies.

Support

For medical questions, ask your doctor. For questions about your Humalog U-200 KwikPen, please contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET. Remember that this information doesn’t replace the advice of your doctor. For additional resources and support, click here.

Eligibility Criteria

By using the Humalog U-200 KwikPen savings card ("Card"), you attest that you meet the eligibility criteria and will comply with the Terms and Conditions described below. Offer void where prohibited by law. This offer is invalid for patients without commercial insurance coverage or those whose prescription claims for Humalog U-200 KwikPen are eligible to be reimbursed, in whole or in part, by any governmental program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medigap, DOD, VA, TRICARE/CHAMPUS, or any State Patient or Pharmaceutical Assistance Program. If you live in Massachusetts, the Card expires on the earlier of: (i) the expiration date of this Card (December 31, 2019); (ii) the date an AB rated generic equivalent for Humalog U-200 KwikPen becomes available; or (iii) June 30, 2017, absent a change in Massachusetts state law. Available only in the US and Puerto Rico to residents of the US and Puerto Rico. By accepting this offer, you agree that if you are required to do so under the terms of your insurance coverage for this prescription or are otherwise required to do so by law, you should notify your insurance carrier of your redemption of this Card. This offer is not valid with any other program, discount, incentive, or similar offer involving Humalog U-200 KwikPen. It is prohibited for any person to sell, purchase or trade; or to offer to sell, purchase or trade, or to counterfeit this Card. This offer may be terminated, rescinded, revoked or amended by Lilly USA, LLC at any time without notice. This Card is not health insurance. This Card expires on 12/31/2019.

Here’s how to get started and pay as little as $25*

*For eligible commercially insured patients.

1 ACTIVATE

Activate your savings card to save

Before you go to the pharmacy, activate your card. It only takes a minute, and it can help you pay as little as $25 for your prescription. For eligible commercially insured patients, please see terms and conditions on back of the savings card or click here.

Activate Card
2 FILL

Fill your prescription

Present your prescription and your activated savings card to your pharmacist. Because Humalog U-200 KwikPen holds twice as much insulin as your previous pen, you'll receive fewer pens per box. Each box has 2 pens instead of 5.

3 START

Start enjoying fewer pen changes

With your new Humalog U-200 KwikPen, you’ll dial and dose with the same single-unit measurements as other disposable mealtime insulin pens.

For example, if you used to dial 10 units of mealtime insulin on Humalog U-100 KwikPen, you’ll still dial 10 on Humalog U-200 KwikPen.

If you used to take mealtime insulin 3 times a day, you'll still take it 3 times a day with Humalog U-200 KwikPen.

Unused pens should be stored in the refrigerator. Do not use your Humalog U-200 KwikPen if it has been frozen. Once a pen has been used for the first time, it can be stored at room temperature. Dispose of your Humalog U-200 KwikPen after 28 days, even if insulin remains.

If you don’t have a Humalog U-200 KwikPen Savings Card and would like one, contact your physician.

As compared with U-100 mealtime insulin pens.

Please see Instructions for Use included with the pen or click here.

The Lilly Answers Center

Talk with your doctor or call if you have questions. We’re here to help.
To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

Using Humalog U-200 KwikPen

These are not the full instructions. Please see the Instructions for Use included with your pen for full instructions.

Watch an instructional video

Full Prescribing Information and Patient Information

Injection instructions for Humalog U-200 KwikPen

These are not the full instructions. Please see the Instructions for Use included with your pen for full instructions.

Preparing

Illustration of hands removing the cap

Step 1

Pull the Pen Cap straight off.

  • Do not twist the cap
  • Do not remove the KwikPen Label

Wipe the Rubber Seal with an alcohol swab.

Humalog should look clear and colorless. Do not use Humalog if it is thick, cloudy, colored, has solid particles or clumps in it.

Illustration of hands removing the paper tab from the outer needle shield

Step 2

Select a new Needle.

Pull the Paper Tab from the Outer Needle Shield.

Illustration of the capped needle being twisted onto the pen

Step 3

Push the capped Needle straight onto the Pen and twist the Needle on until it is tight.

Illustration of the outer needle shield being disconnected from the pen.

Step 4

Pull off the Outer Needle Shield. Do not throw it away.

Pull off the Inner Needle Shield and throw it away.

Priming

Prime before each injection. Priming ensures the Pen is ready to use and removes air that may collect in the cartridge during normal use.
If you do not prime before each injection, you may get too much or too little insulin.

Illustration of hand turning Dose Knob

Step 5

Turn the Dose Knob to select 2 units.

Illustration of hands holding needle pointing up while tapping the cartridge holder to collect air bubbles

Step 6

Hold your Pen with the Needle pointing up. Tap the Cartridge Holder gently to collect air bubbles at the top.

Illustration of pen being held up with hand pushing the dose knob upward. Also close-ups of the needle tip and the dose window stopped at “0.”

Step 7

Continue holding your Pen with the Needle pointing up. Push the Dose Knob in until it stops and “0” is seen in the Dose Window. Hold the Dose Knob in and count to 5 slowly.

  • You should see insulin at the tip of the needle
    • If you do not see insulin, repeat the priming (steps 5 to 7), up to but not more than 8 times
    • If you still do not see insulin, change the Needle and repeat steps 5 to 7

Small air bubbles are normal and will not affect your dose.

Selecting the Dose

This Pen has been designed to deliver the dose that is shown in the window. Dial your usual dose as instructed by your doctor.

Illustration of hands turning Dose Knob to a unit number between 14 and 16

Step 8

Turn the Dose Knob to select the number of units you need to inject. The Dose Indicator should line up with your dose.

  • The Dose Knob clicks as you turn it. Each click of the Dose Knob dials 1 unit at a time
  • Do not dial your dose by counting the clicks because you may dial the wrong dose
  • The dose can be corrected by turning the Dose Knob in either direction until the correct dose lines up with the Dose Indicator
  • The even numbers are printed on the dial
  • The odd numbers, after the number 1, are shown as full lines

Always check the number in the Dose Window to make sure you have dialed the correct dose.

  • The Pen will not let you dial more than the number of units left in the Pen
  • If your dose is more than the number of units left in the Pen, you may either:
    • Inject the amount left in your Pen and then use a new Pen to give the rest of your dose, or
    • Get a new Pen and inject the full dose
  • The Pen is designed to deliver a total of 600 units of insulin. The cartridge contains an additional small amount of insulin that cannot be delivered. Do not transfer this to a syringe. Severe overdose can result

Injecting

  • Inject your insulin as your doctor has shown you
  • Change (rotate) your injection site for each injection
  • Do not try to change your dose while injecting
Illustration of a front and back view of the human body with the possible injection areas are highlighted

Step 9

Choose your injection site.

Humalog is injected under the skin (subcutaneously) of your stomach area, buttocks, upper legs, or upper arms.

Wipe the skin with an alcohol swab, and let the injection site dry before you inject your dose.

Illustration of person almost injecting U-200 into stomach region.

Step 10

Insert the Needle into your skin.

Illustration of person injecting U-200 into stomach pushing down on the Dose Knob

Step 11

Put your thumb on the Dose Knob and push the Dose Knob in until it stops.

Hold the Dose Knob in and slowly count to 5.

Illustration of the U-200 Dose Window that reads 0.

Step 12

Pull the Needle out of your skin.

You should see “0” in the Dose Window. If you do not see “0” in the Dose Window, you did not receive your full dose.

If you see blood after you take the Needle out of your skin, press the injection site lightly with a piece of gauze or an alcohol swab. Do not rub the area.

A drop of insulin at the Needle tip is normal. It will not affect your dose.

If you do not think you received your full dose, do not take another dose. If you have questions, call your doctor.

Illustration of Outer Needle Shield being put back on the pen

Step 13

Carefully replace the Outer Needle Shield.

Illustration of hands unscrewing the capped needle.

Step 14

Unscrew the capped Needle and throw it away.

Do not store the Pen with the Needle attached to prevent leaking, blocking of the Needle, and air from entering the Pen.

Illustration of hands fastening the pen cap back onto the pen.

Step 15

Replace the Pen Cap by lining up the Cap Clip with the Dose Indicator and pushing straight on.

After injecting

Put used Needles in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose Needles in your household trash.

Frequently Asked Questions

How is Humalog U-200 KwikPen different from my current U-100 pen?

The difference is that Humalog U-200 KwikPen holds double the mealtime insulin. You will still dial and dose* in the same single-unit increments as Humalog U-100 KwikPen.

*Please see Instructions for Use.

Is the U-200 pen larger than other U-100 mealtime insulin pens because it holds twice the insulin?

No, it is similar in size to other U-100 pens and the same size as the Humalog U-100 KwikPen.

How were you able to fit double the insulin in one pen?

Humalog U-200 KwikPen contains U-200 mealtime insulin, an insulin that’s twice the concentration of Humalog U-100. It allows us to put twice as many units of insulin in the same liquid volume. But don’t worry, we’ve designed the Humalog U-200 KwikPen so that you don’t have to do any math or calculations to get the correct amount of insulin. You will dial and dose* with the same single-unit measurements as other disposable U-100 mealtime insulin pens.

*Please see Instructions for Use.

Does the insulin in Humalog U-200 KwikPen work the same as the insulin in Humalog U-100 KwikPen?

The insulin in your Humalog U-200 KwikPen works just like Humalog U-100 insulin to lower your blood sugar. Humalog U-200 insulin is a rapid-acting insulin used to treat people with diabetes for the control of high blood sugar.

Does this mean I will have fewer injections?

No, you will still follow the mealtime insulin therapy schedule prescribed by your doctor.

What do I do with my remaining U-100 mealtime insulin pens?

You may use your remaining U-100 mealtime insulin pens as long as they have not expired, unless otherwise directed by your doctor.

How long does U-200 KwikPen last once I’ve begun using it?

You will need to discard your Humalog U-200 KwikPen after 28 days in use, even if insulin remains.

Will there be insulin left in my pen when it’s time to discard it?

Each Humalog U-200 KwikPen contains 600 units of mealtime insulin instead of the 300 units of mealtime insulin found in U-100 pens. If you go through 3 or more U-100 pens a month, you should be able to use an entire Humalog U-200 KwikPen within 28 days. Remember: Never withdraw Humalog U-200 from the pen using a syringe. It could result in a severe overdose.

Where can I get a Humalog U-200 KwikPen savings card?

If you have insurance through your employer or independent insurance that is not a government-sponsored plan (for example, Medicaid or Medicare), ask your doctor for a Humalog U-200 KwikPen savings card.

Why do I have to activate my Humalog U-200 KwikPen savings card?

Activating your Humalog U-200 KwikPen savings card ensures that your card is ready for use and that you meet the eligibility requirements. It also offers the opportunity for you to sign up to receive continued information about this and other products.

Why am I only getting two pens per box?

Humalog U-200 KwikPen has double the mealtime insulin, so you do not need as many pens per month.

What if I feel like I am not getting enough pens at the pharmacy?

Because Humalog U-200 KwikPen holds twice as many units of insulin as the U-100 pen, you will receive fewer pens from the pharmacy each month. Pens are packaged 2 per box. If you feel you are not getting enough insulin to meet your dosing needs, talk to your doctor.

Is Humalog U-200 mealtime insulin available in a vial?

No, it is currently only available in a KwikPen. Remember: Never withdraw Humalog U-200 from the pen using a syringe. It could result in a severe overdose. You should always carry a backup pen.

Are you going to discontinue selling Humalog U-100 and Humalog U-100 KwikPen?

No. These products are still available by prescription.

Do I still prime my pen before using it?

Yes, you still need to prime it. You will turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and zero is seen in the dose window. Hold the dose knob in and count to 5 slowly. You may see more of a droplet of insulin on the needle than a stream.

Where do I inject U-200 insulin?

Rotate between typical injection sites, such as the abdomen, buttocks, upper legs, or upper arms. View the demonstration video for more information.

What should I do if my KwikPen is jammed?

Your pen may be jammed if it is difficult to inject a dose or dial a dose. To clear the jam:

  • Attach a new needle. When you do this you may see insulin come out of the needle
  • Prime the pen
  • Dial your dose and inject

Do not withdraw insulin from the pen with a syringe. If the dose knob is still difficult to push, contact your pharmacy or The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979). View the demonstration video for more information.

Are the potential side effects of U-200 similar to those of U-100?

Yes, low blood sugar is the most common side effect. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site. Please see Important Safety Information for additional side effects. Ask your doctor for more information or for medical advice.

What should I do if I am experiencing any side effects?

If you are experiencing any side effects, please contact your doctor. You may also report side effects to the Food and Drug Administration at 1-800-FDA-1088 or contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

The Lilly Answers Center

Talk with your doctor or call if you have questions. We’re here to help.
To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

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