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Indication for Humalog Brand of Insulins

Humalog® is used to treat people with diabetes for the control of blood sugar. Humalog® Mix75/25 (75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50 (50% insulin lispro protamine suspension and 50% insulin lispro injection) are used to treat adults with diabetes for the control of high blood sugar.

Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog.

Important Safety Information for Humalog Brand of Insulins

What is the most important information I should know about Humalog, Humalog 200 units/mL KwikPen, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not share your Humalog, Humalog Mix75/25, or Humalog Mix50/50 KwikPen, cartridges, reusable pen compatible with Lilly 3 mL cartridges, or syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • Humalog 200 units/mL KwikPen contains 2 times as much insulin (200 units/mL) in 1 mL as standard insulin (100 units/mL).
  • The Humalog contained in the Humalog U-200 KwikPen should ONLY be injected with the Humalog U-200 KwikPen. Do NOT withdraw Humalog U-200 from the pen using a syringe. It could result in an overdose causing severe low blood sugar which may put your life in danger.
  • Do not change the insulin you use without talking to your healthcare provider. Changes may make you more likely to experience low or high blood sugar. Changes should be made cautiously under the supervision of your healthcare provider.
  • Test your blood sugar levels as your healthcare provider instructs.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.
  • When used in a pump, do not mix or dilute Humalog U-100 with any other insulin or liquid. Do NOT use Humalog U-200, Humalog Mix75/25 or Humalog Mix50/50 in a pump.

Who should not take Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.

Before using Humalog, Humalog Mix75/25, or Humalog Mix50/50, what should I tell my healthcare providers?

  • About all of your medical conditions, including liver, kidney, or heart failure or other heart problems.
  • If you are pregnant, planning to become pregnant, or are breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and nonprescription medicines, vitamins, and herbal supplements.

How should I use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating.
  • Always make sure that you receive the correct type of insulin from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or milky after mixing.
  • Do not mix Humalog U-100 with insulin other than NPH when using a syringe. Do not mix or dilute Humalog U-100 when used in a pump.
  • Never mix Humalog Mix75/25 or Humalog Mix50/50 in the same syringe with other insulin products. Never use Humalog U-200, Humalog Mix75/25 or Humalog Mix50/50 in a pump.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Do not re-use needles. Always use a new needle for each injection. Re-use of needles can cause you to receive the wrong dose of Humalog and result in infection.
  • Do not drive or operate heavy machinery until you know how Humalog affects you. Do not use alcohol while using Humalog.

What are the possible side effects of Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Severe low blood sugar can cause unconsciousness (passing out), seizures, and death. Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much insulin. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 can cause life-threatening low potassium in your blood (hypokalemia), which can cause severe breathing problems, irregular heartbeat, and death.
  • Serious side effects can include swelling of your hands and feet and heart failure when taking certain pills called thiazolidinediones or “TZDs” with Humalog, Humalog Mix75/25, or Humalog Mix50/50. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs, Humalog, Humalog Mix75/25, or Humalog Mix50/50.
  • Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in case of pump failure.
  • The most common side effects of Humalog include low blood sugar, allergic reactions, including reactions at your injection site, skin thickening or pits at the injection site (lipodystrophy), itching, and rash. These are not all of the possible side effects. Ask your healthcare provider for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit fda.gov/medwatch or call 1-800-FDA-1088.

For additional information talk to your healthcare providers and please click to access Humalog Full Prescribing Information, Humalog U-100 Patient Prescribing Information, Humalog U-200 KwikPen Patient Prescribing Information, Humalog Mix75/25 Full Prescribing Information and Patient Prescribing Information, and Humalog Mix50/50 Full Prescribing Information and Patient Prescribing Information.

Please see Instructions for Use included with your pen.

HI U200 BOI CON ISI 26MAY2015

Humalog® and Humalog® KwikPen® are registered trademarks of Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Humalog® Mix75/25, Humalog® Mix50/50, Humalog® Mix75/25 KwikPen®, and Humalog® Mix50/50 KwikPen® are trademarks of Eli Lilly and Company and are available by prescription only.

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Indication for Humalog Brand of Insulins

Humalog® is a rapid-acting human insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. Humalog® Mix75/25 (75% insulin lispro protamine suspension and 25% insulin lispro injection) and Humalog® Mix50/50 (50% insulin lispro protamine suspension and 50% insulin lispro injection) are indicated in the treatment of adults with diabetes mellitus for the control of hyperglycemia.

Important Safety Information for Humalog Brand of Insulins

Contraindications

  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 are contraindicated during episodes of hypoglycemia and in patients who are hypersensitive to Humalog or any of its excipients.

Warnings and Precautions

  • Never Share a Humalog KwikPen, Humalog Mix75/25 KwikPen, or Humalog Mix50/50 KwikPen, Cartridge, Reusable Pen Compatible with Lilly 3 mL Cartridges, or Syringe Between Patients: Humalog, Humalog Mix75/25, and Humalog Mix50/50 KwikPens, cartridges, and reusable pens compatible with Lilly 3 mL cartridges must never be shared between patients, even if the needle is changed. Patients using Humalog, Humalog Mix75/25, or Humalog Mix50/50 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens.
  • Changes in Insulin Regimen: Changes may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased.
  • Hypoglycemia: Severe hypoglycemia may be life threatening and can cause seizures or death. Hypoglycemia is the most common adverse reaction of Humalog, Humalog Mix75/25, and Humalog Mix50/50. The patient’s ability to concentrate and react may be impaired as a result of hypoglycemia. Hypoglycemia can happen suddenly and symptoms may vary for each person and may change over time. Early warning symptoms of hypoglycemia may be different or less pronounced under conditions such as long-standing diabetes, diabetic nerve disease, use of medications such as beta-blockers, or in patients who experience recurrent hypoglycemia. These situations may result in severe hypoglycemia and possibly loss of consciousness prior to the patient’s awareness of hypoglycemia.
  • Timing of hypoglycemia usually reflects the time-action profile of administered insulins which may vary in different individuals or at different times in the same individual. Other factors such as changes in food intake, injection site, exercise, and concomitant medications may increase the risk of hypoglycemia.
  • Educate patients to recognize and manage hypoglycemia. In patients at higher risk for hypoglycemia and patients with reduced symptomatic awareness, increased frequency of blood glucose monitoring is recommended. Patients with renal or hepatic impairment may be at higher risk of hypoglycemia.
  • Hypoglycemia Due to Medication Errors: Instruct patients to always check the insulin label before each injection to avoid medication errors.
  • Humalog U-200 should not be transferred from the Humalog KwikPen to a syringe as overdose and severe hypoglycemia can occur.
  • Hypersensitivity Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with Humalog, Humalog Mix75/25, and Humalog Mix50/50. If hypersensitivity reactions occur, discontinue the use of insulin and treat per standard of care until signs and symptoms resolve.
  • Hypokalemia: Hypokalemia may be life threatening. Insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50, cause a shift in potassium from the extracellular to intracellular space possibly leading to hypokalemia, which, if untreated, may result in respiratory paralysis, ventricular arrhythmia, and death. Monitor potassium levels in patients at risk for hypokalemia (eg, patients using potassium-lowering medications or medications sensitive to serum potassium concentrations).
  • Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Thiazolidinediones (TZDs), which are PPAR-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. This may lead to or exacerbate heart failure. Observe patients for signs and symptoms of heart failure and consider discontinuation or dose reduction of the PPAR-gamma agonist.
  • Hyperglycemia and Ketoacidosis Due to Insulin Pump Device Malfunction: Malfunction of the insulin pump device, infusion set, or insulin degradation can rapidly lead to hyperglycemia and ketoacidosis. Patients using subcutaneous insulin infusion pumps must be trained to administer insulin by injection and have alternate insulin therapy available in case of pump failure.

Drug Interactions

  • Some medications may alter glucose metabolism, insulin requirements, and the risk for hypoglycemia or hyperglycemia. Signs of hypoglycemia may be reduced or absent in patients taking anti-adrenergic drugs. Particularly close monitoring may be required.

Adverse Reactions

  • Adverse reactions associated with Humalog include hypoglycemia, hypokalemia, allergic reactions, injection-site reactions, lipodystrophy, pruritus, rash, weight gain, and peripheral edema.

Use in Specific Populations

  • Humalog has not been studied in children with type 1 diabetes less than 3 years of age or in children with type 2 diabetes. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established.

Dosage and Administration

  • Humalog should be given within 15 minutes before or immediately after a meal.
  • Humalog Mix75/25 and Humalog Mix50/50 should be given within 15 minutes before a meal.
  • Humalog U-100 can be administered intravenously under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia. Do NOT administer Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 intravenously.
  • Humalog U-100 for subcutaneous injection should only be mixed with NPH insulin. If Humalog U-100 is mixed with NPH insulin, Humalog should be drawn into the syringe first. Injection should occur immediately after mixing. Do NOT mix Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 in a syringe with any other insulin.
  • Humalog U-100 should not be diluted or mixed when used in an external insulin pump. Change Humalog U-100 in the reservoir at least every 7 days. Change the infusion set and insertion site at least every 3 days. Do NOT use Humalog Mix75/25, Humalog Mix50/50, or Humalog U-200 in a subcutaneous insulin infusion pump.
  • Do NOT perform dose conversion when using either the Humalog U-100 or Humalog U-200 KwikPens. The dose window shows the number of insulin units to be delivered and no conversion is needed.

Please click to access Humalog Full Prescribing Information, Humalog Mix75/25 Full Prescribing Information, and Humalog Mix50/50 Full Prescribing Information.

Please see Instructions for Use included with the pen.

HI BOI U200 HCP ISI 26MAY2015

Humalog® and Humalog® KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates, and are available by prescription only.

Humalog® Mix75/25, Humalog® Mix50/50, Humalog® Mix75/25 KwikPen®, and Humalog® Mix50/50 KwikPen® are trademarks of Eli Lilly and Company and are available by prescription only.

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Humalog vial and Humalog KwikPen

About
Humalog®
Mixes

Humalog® Mix75/25 and Humalog® Mix50/50 are combinations of fast- and longer-acting insulin that work together to help manage your blood sugar between meals and at night, as well as blood sugar “spikes” that can happen when you eat. Test your blood sugar levels as your doctor instructs.

  • Low blood sugar (hypoglycemia) is the most common side effect of Humalog mixes that may be severe and cause seizures and death
  • Because Humalog mixes start working faster than other insulins that contain regular human insulin, it’s very important to take them within 15 minutes before eating a meal to help prevent low blood sugar
  • It’s normal for blood sugar readings to fluctuate from day to day
  • Make sure you understand how many units your doctor wants you to take and with what meals
Close-up of U-100 pen dose knob horizontal

Easy to deliver the dose

Easy to set and see the dose

Easy to dial up and back down for dose selection

Using Humalog Premixed Insulin KwikPen

Humalog® KwikPen® is a small, lightweight pen that’s prefilled with mealtime insulin. Plus, since it shouldn't be refrigerated after the first use, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it’s the size of a marker.

Once you start using Humalog KwikPen, it should be stored at room temperature, below 86°F (30°C), and must be used within 10 days or be discarded, even if it still contains Humalog.

How to use Humalog® Mix75/25 KwikPen® and Humalog® Mix50/50 KwikPen®

These are not the full instructions. Please see the Instructions for Use included with your pen for full instructions.

Humalog Mix75/25

Full Prescribing Information and Patient Information

Humalog Mix50/50

Full Prescribing Information and Patient Information

Injection instructions for Humalog Mix75/25 and Humalog Mix 50/50 KwikPen

These are not the full instructions. Please see the Instructions for Use included with your pen for full instructions.

Preparing

Illustration of hands removing the cap

Step 1

Pull the Pen Cap straight off.

Wipe the Rubber Seal with an alcohol swab.

  • Do not twist the cap
  • Do not remove the KwikPen Label
Illustration of hands rolling the pen

Step 2a

Gently roll the Pen between your hands 10 times.

Illustration of hand inverting pen (like a rotation) upside down.

Step 2b

Move the Pen up and down as shown here (invert it) 10 times.

Mixing by rolling and inverting is important to ensure the correct dose.

Humalog Mix75/25 and Humalog Mix50/50 should look white and cloudy after mixing.

Do not use if it looks clear or contains any lumps or particles.

Illustration of hands removing the paper tab from the outer needle shield

Step 3

Select a new Needle.

Pull the Paper Tab from the Outer Needle Shield.

Illustration of the capped needle being twisted onto the pen

Step 4

Push the capped Needle straight onto the Pen and turn the Needle forward until it is tight.

Illustration of the outer needle shield being disconnected from the pen.

Step 5

Pull off the Outer Needle Shield. Do not throw it away.

Pull off the Inner Needle Shield and throw it away.

Priming

Prime before each injection. Priming ensures KwikPen is ready to use and removes air that may collect in the cartridge during normal use.

If you do not prime KwikPen before each injection, you may get too much or too little insulin.

Illustration of hand turning Dose Knob

Step 6

Turn the Dose Knob to select 2 units.

Illustration of hands holding needle pointing up while tapping the cartridge holder to collect air bubbles

Step 7

Hold the Pen with the Needle pointing up. Tap the Cartridge Holder gently to collect air bubbles at the top.

Illustration of pen being held up with hand pushing the dose knob upward. Also close-ups of the needle tip and the dose window stopped on “0.”

Step 8

Hold the Pen with the Needle pointing up. Push the Dose Knob in until it stops and "0" is seen in the Dose Window. Hold the Dose Knob in and count to 5 slowly.

  • You should see a stream of insulin from the Needle
    • If you do not see a stream of insulin, repeat steps 6 to 8, no more than 4 times
    • If you still do not see a stream of insulin, change the Needle and repeat steps 6 to 8

Selecting the Dose

Illustration of hands turning Dose Knob to a unit number between 14 and 16

Step 9

Turn the Dose Knob to select the number of units you need to inject. The Dose Indicator should line up with your dose.

  • The dose can be corrected by turning the Dose Knob in either direction until the correct dose lines up with the Dose Indicator
  • The even numbers are printed on the dial. The odd numbers, after the number 1, are shown as full lines

KwikPen will not let you dial more than the number of units left in the Pen. If the needed dose is more than the number of units left in the Pen, you may either:

  • Inject the amount left in the Pen and then use a new KwikPen to deliver the rest of the dose
  • OR
  • Get a new KwikPen and inject the full dose

KwikPen is designed to deliver a total of 300 units of insulin. The cartridge contains an additional small amount of insulin that cannot be delivered.

Injecting

  • Inject your insulin as instructed here or by your doctor
  • Change (rotate) the injection site for each injection
  • Do not try to change your dose while injecting
Illustration of a front and back view of the human body with the possible injection areas are highlighted

Step 10

Choose your injection site.

Humalog Mix75/25 and Humalog Mix50/50 are injected under the skin (subcutaneously) of your stomach area, buttocks, upper legs, or upper arms.

Wipe the skin with an alcohol swab, and let the injection site dry before you inject your dose.

Illustration of person almost injecting U-100 into stomach region.

Step 11

Insert the Needle into your skin.

Illustration of person injecting U-100 into stomach pushing down on the Dose Knob

Step 12

Put your thumb on the Dose Knob and push the Dose Knob in until it stops. Hold the Dose Knob in and slowly count to 5.

Illustration of the U-100 Dose Window that reads 0.

Step 13

Pull the Needle out of your skin.

  • You should see "0" in the Dose Window
    • If you do not see "0" in the Dose Window, you did not receive your full dose
    • If you see blood after you take the Needle out of your skin, press the injection site lightly with a piece of gauze or an alcohol swab. Do not rub the area

A drop of insulin at the Needle tip is normal. It will not affect the dose.
If you do not think you received your full dose, do not take another dose. Call Lilly or your doctor for assistance.

Illustration of Outer Needle Shield being put back on the pen

Step 14

Carefully replace the Outer Needle Shield.

Illustration of hands unscrewing the capped Needle.

Step 15

Unscrew the capped Needle and throw it away.

Do not store KwikPen with the Needle attached, to prevent leaking, blocking of the Needle, and/or air from entering the Pen.

Illustration of hands fastening the Pen Cap back onto the Pen.

Step 16

Replace the Pen Cap by lining up the Cap Clip with the Dose Indicator and pushing straight on.

After injecting

Put used Needles in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose Needles in your household trash.

The Lilly Answers Center

Talk with your doctor or call if you have questions. We’re here to help.
To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

Where to inject Humalog Mix75/25 and Humalog Mix50/50

Humalog Mix75/25 and Humalog Mix50/50 may be injected under the skin of the stomach area, back of upper arms, upper legs, or buttocks (see diagram). Never inject Humalog mixes into a muscle or vein. Work with your doctor to determine the most appropriate injection sites.

Be sure to use a different injection site each time and do not overuse any site.

Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.

Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your doctor. Do not inject insulin into a skin area that is red, swollen, or itchy.

Front side appropriate injection sites. Stomach, upper legs, back of upper arms.
Back side appropriate injection sites. Back of upper arms, buttocks
 

Storage and disposal for Humalog KwikPen

Refrigerator

Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.

Fire flame

Humalog should be stored away from light and heat.

Snowflake

Do not use insulin if it has been frozen.

Thermometer

Opened cartridges or prefilled pens should be kept at room temperature.

28 days calendar

Prefilled pens and cartridges should be thrown away 10 days after the first use even if there is insulin remaining.

Toxic Garbage Can

Dispose of needles and pens as directed by your doctor.

Other ways to take Humalog mixes

There are other ways to take Humalog mixes besides the KwikPen. Both premixed insulins are available in a vial. You and your doctor should discuss which option would be best for you.

Click here to learn how to use a vial and syringe for Humalog mixes.

vials of Humalog Mixes

The Lilly Answers Center

Talk with your doctor or call if you have questions. We’re here to help.
To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

Storage and disposal for vials

Icon: Refrigerator

Store all unopened (unused) vials in the original carton in a refrigerator. Do not freeze.

Icon: Refrigerator and vial

Unopened, refrigerated vials can be kept until expiration date.

Icon: Thermometer

After first use (opened), store vial in the refrigerator (not the freezer) or, if necessary, at room temperature below 86°F (30°C). Do not use if vial has been frozen.

Icon: 28 days calendar

Throw away open vials 28 days after first use, even if there is insulin left in the vial.

Icon: Toxic Garbage Can

Do not use after the expiration date printed on the carton and label.

Icon: Avoid Sunlight

Protect from direct heat and light.

Safely dispose of needles and syringes as directed by your doctor.

For full storage and disposal information, please see the Patient Information leaflet that comes with your insulin.

Disposal of needles and syringes

Icon: Toxic Garbage Can

Place all needles and syringes in a sharps disposal container immediately after they have been used.

  • Never place loose needles in any trash can or recycling bin and never flush them down the toilet
  • Carry a small, travel-size sharps disposal container when leaving home
Icon: Do not reuse sharps containers

Dispose of the sharps container according to community guidelines.

  • Do not reuse sharps containers

For information about disposal of syringes and needles, visit the US Food and Drug Administration website at fda.gov/safesharpsdisposal or call 1-888-INFO-FDA (1-888-463-6332).

Frequently Asked Questions

How long does Humalog KwikPen last once I’ve begun using it?

You will need to discard your Humalog KwikPen after 10 days in use, even if insulin remains.

Will there be insulin left in my pen when it’s time to discard it?

KwikPen is designed to deliver a total of 300 units of insulin. The cartridge contains an additional small amount of insulin that cannot be delivered, so you will see a small amount of insulin left in your pen when it's time to discard it. Remember: Never withdraw Humalog from the pen using a syringe. It could result in an overdose causing severe low blood sugar, which may put your life in danger.

Must I prime my pen before using it?

Yes, you need to prime your pen. You will turn the dose knob to 2 units. Hold your pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top. Continue holding your pen with the needle pointing up. Push the dose knob in until it stops and zero is seen in the dose window. Hold the dose knob in and count to 5 slowly. A stream of insulin should be seen from the needle. You may see more of a droplet of insulin on the needle than a stream.

Where do I inject Humalog Mix75/25 or Humalog Mix50/50 insulin?

Rotate between typical injection sites, such as the abdomen, buttocks, upper legs, or upper arms. View the demonstration video for more information.

What should I do if my KwikPen is jammed?

Your pen may be jammed if it is difficult to inject a dose or dial a dose. To clear the jam:

  • Attach a new needle. When you do this you may see insulin come out of the needle
  • Prime the pen
  • Dial your dose and inject

Do not withdraw insulin from the pen with a syringe. If the dose knob is still difficult to push, contact your pharmacy or The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979). View the demonstration video for more information.

What are the potential side effects for Humalog Mix75/25 or Humalog Mix50/50?

Low blood sugar is the most common side effect. Other possible side effects include severe life-threatening allergic reactions and reactions at the injection site. Please see Important Safety Information for additional side effects. Ask your doctor for more information or for medical advice.

What should I do if I am experiencing any side effects?

If you are experiencing any side effects, please contact your doctor. You may also report side effects to the Food and Drug Administration at 1-800-FDA-1088 or contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

The Lilly Answers Center

Talk with your doctor or call if you have questions. We’re here to help.
To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979), Monday through Friday from 9 AM to 8 PM ET.

You clicked on a page that’s meant for healthcare providers.

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