Humalog (insulin lispro injection [rDNA origin])

Humalog is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Glucagon (Glucagon for Injection [rDNA origin]) is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).

Select an option below, and we'll give you a list of pages you should visit on Humalog.com:

Look for the discussion guide icon throughout the site and click on it to create your discussion guide. Print and take it with you to your next visit with your healthcare provider.

Insulin pens offer a convenient way to carry insulin with you in a discreet way. They provide accurate dosing and come in both prefilled and reusable options. In this section, you'll find detailed information about our prefilled and reusable insulin pens, including online tutorials that show you how to use the pens.

Humalog^®, Humalog^® Mix75/25™, and Humalog^® Mix50/50™ are also available by prescription in the original Humalog and Humalog Mixtures Prefilled Pens.

Before use, carefully read the Humalog KwikPen User Manual, HumaPen MEMOIR User Manual, HumaPen LUXURA HD User Manual, or original Prefilled Pen User Manual.

Humalog (insulin lispro injection [rDNA origin]), Humalog Mix75/25 (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog Mix50/50 (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in these insulins.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog is an injectable, fast-acting insulin. Humalog Mix75/25 and Humalog Mix50/50 are a mixture of fast-acting and longer-acting insulins. These insulins start working faster than other insulins that contain regular human insulin. Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be taken within 15 minutes before a meal. Humalog can be taken right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. The safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog, Humalog Mix75/25, or Humalog Mix50/50 in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life-threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole body allergic reactions are less common, but may be life-threatening.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information.

Humalog insulins are available by prescription only.

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Humalog^® is a registered trademark of Eli Lilly and Company and is available by prescription only.
Humalog^® Mix75/25™ and Humalog^® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.
HumaPen^® MEMOIR™ and HumaPen^® LUXURA™ HD are trademarks of Eli Lilly and Company and are available by prescription only.
Humalog^® KwikPen™, Humalog^® Mix75/25™ KwikPen™, and Humalog^® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.
The glucagon design is a trademark of Eli Lilly and Company.