Type 2 diabetes Humalog® improved glycemic control
When added to a basal insulin in patients with type 2 diabetes, Humalog dosed 15 minutes before or immediately after meals:
- Reduced postprandial glucose (PPG) levels1
- Lowered A1C2
Why postprandial glucose matters3
The overall measurement of glycemic control (A1C) reflects a combination of both fasting plasma glucose (FPG) and postprandial glucose (PPG).3 Ninety-nine percent of patients with A1C values greater than or equal to 7% have 2-hour PPG greater than or equal to 200 mg/dL.4 As your patient’s A1C levels approach the normal range, PPG contributes more to the A1C than FPG.3 Therefore, management of postprandial hyperglycemia is important for achieving recommended A1C goals.
As A1C levels approach the normal range, PPG contributes more to the A1C than FPG3
- PPG=postprandial plasma glucose
- FPG=fasting plasma glucose
The relative contribution of fasting and postprandial blood glucose varies with A1C.
Humalog U-100 compared to regular human insulin
Compared to regular insulin, Humalog U-100 lowered 2-hour postprandial glucose excursions
*In a study of 722 patients with type 2 diabetes, the increase in serum glucose levels at 2 hours following the test meal was 53% lower for Humalog relative to regular human insulin. P<.001. Actual values for the rise in glucose were 25.4 ± 1.8 mg/dL for Humalog vs 54.0 ± 1.8 mg/dL for regular human insulin.
Humalog U-200 is bioequivalent to Humalog U-1001
It provides the same rapid onset and same duration of action. Bioequivalency was determined by area under the curve and maximum concentration.Learn more about Humalog U-200 efficacy ▶ Learn about efficacy with the Humalog U-100 self-titration algorithm ▶
Select Safety Information
Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with Humalog, Humalog Mix75/25, and Humalog Mix50/50. If hypersensitivity reactions occur, discontinue the insulin and treat per standard of care until signs and symptoms resolve.