Vial and Syringe Instructions

Your healthcare provider or diabetes educator will explain how to take your Humalog^® insulin injection. He or she will then watch you do the following steps.

Preparing a dose of insulin
Wash your hands. If an insulin mixture (cloudy insulin), gently mix the insulin by: Rolling the vial between the palms of your hands. Turning the vial over from end to end a few times until completely mixed.
If this is a new vial, remove the flat, colored cap, but not the rubber stopper or the metal band under the cap. Clean the rubber stopper with an alcohol swab.
Remove the cover from the needle. Pull the plunger back to pull air into the syringe. Pull back until the tip of the plunger is at the line for the number of units required.
Push the needle through the rubber stopper. Make sure the tip of the needle is not in the insulin. Press the plunger to push air into the vial of insulin.
Turn the vial and syringe upside down. Now the tip of the needle should be in the insulin. Holding the vial with one hand, use the other to pull back on the plunger, which will pull insulin into the syringe. Stop when the plunger is at the line for your dose. Look at the insulin in the syringe. If you see any air bubbles: Use the plunger to push the insulin back into the vial. Then slowly pull the plunger back to the line for your dose of insulin. Repeat this until there are no large air bubbles in the syringe.
Make sure the tip of the plunger is at the line showing your dose of insulin. Double check your dose. Magnifiers are available if needed to help you see more clearly. Pull the needle out of the rubber stopper. If you need to lay the needle down before taking your shot, put the cover back on the tip to protect it.
Choose an injection site. Make sure the skin is clean. Pinch up a large area of skin. Push the needle into the skin, going straight in at a 90 degree angle. Make sure the needle is all the way in.
Push the plunger all the way down to inject the insulin into your body. Release the pinched skin, count to five slowly, and pull the needle straight out. Do not rub the place where you gave your injection. Safely dispose of used syringes. Your healthcare provider, pharmacist, diabetes educator, or state health authorities can tell you how.

Your healthcare provider may want you to take more than one type of insulin. For example, you may need a combination of rapid-acting and longer-acting insulin to keep your blood sugar in the target range.

There are two ways to do this:

Use a premixed insulin. This method does not require you to mix insulin yourself.
Mix the two types of insulin yourself. Ask your healthcare provider if it is OK to mix your rapid-acting and longer-acting insulins together. If the answer is yes, follow the procedure below.

Preparing a mixed dose of insulin
Clean the tops of both vials with an alcohol swab. Inject (a) units of air into the longer-acting (cloudy) insulin bottle. Do not pull insulin into the syringe. Take the needle out of the vial.
Inject (b) units of air into the rapid-acting (clear) insulin vial. Turn the vial and syringe upside down. Hold the vial with one hand. Use the other hand to pull back on the plunger until you have your required dose of rapid-acting insulin in the syringe. Be sure to remove any large air bubbles. Take the needle out of the vial.
Gently roll or shake the longer-acting insulin vial until it is mixed. Insert the needle into the vial of longer-acting insulin. Turn the vial and syringe upside down. Hold the vial with one hand. Use the other hand to pull back on the plunger. Pull the plunger back until you have a total of both equaled to (a + b) your total prescribed insulin dosage, as recommended by your physician. Be careful not to push any of the rapid-acting insulin into the longer-acting insulin vial. Remove the needle from the vial.
Choose an injection site. Make sure the skin is clean. Pinch up a large area of skin. Push the needle into the skin, going straight in at a 90 degree angle. Make sure the needle is all the way in.
Push the plunger all the way down to inject the insulin into your body. Release the pinched skin, count to five slowly, and pull the needle straight out. Do not rub the place where you gave your injection. Safely dispose of used syringes. Your healthcare provider, pharmacist, diabetes educator, or state health authorities can tell you how.

(a) Units reflects your healthcare provider's recommendation for units of longer-acting insulin.

(b) Units reflects your healthcare provider's recommendation for units of rapid-acting insulin.

Note: Work with your healthcare provider if you are mixing insulin for guidance on the best way to manage this.

Humalog is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog (insulin lispro injection [rDNA origin]) is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in Humalog.

Humalog is an injectable, fast-acting insulin. Humalog starts working faster than other insulins that contain regular human insulin. Take Humalog within 15 minutes before eating or right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole-body allergic reactions are less common, but may be life threatening.

Pumps
When used in an external insulin pump, Humalog should not be diluted or mixed with any other insulin. Humalog administration in insulin pumps has not been studied in patients with type 2 diabetes. The infusion set and Humalog should be replaced and a new infusion site selected every 48 hours or less. Glucose monitoring is particularly important for patients using an external insulin pump. Humalog in the external pump should not be exposed to temperatures above 37°C (98.6°F).

Humalog was tested in the MiniMed^® Models 506, 507, and 508 insulin pumps using MiniMed^® Polyfin^® infusion sets.

Humalog was also tested in Disetronic^® H-TRONplus^® V100 insulin pump (with plastic 3.15 mL insulin reservoir), and the Disetronic D-TRON^® and D-TRONplus^® insulin pumps (with Humalog 3 mL cartridges) using Disetronic Rapid^® infusion sets. A Humalog 3 mL cartridge used in the D-TRON or D-TRONplus should be discarded after 7 days, even if it still contains Humalog. Infusion sets, D-TRON and D-TRONplus cartridge adapters, and Humalog in the external insulin pump reservoir should be discarded every 48 hours or less.

Humalog (insulin lispro injection [rDNA origin]), Humalog Mix75/25 (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog Mix50/50 (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in these insulins.

Humalog is an injectable, fast-acting insulin. Humalog Mix75/25 and Humalog Mix50/50 are a mixture of fast-acting and longer-acting insulins. These insulins start working faster than other insulins that contain regular human insulin. Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be taken within 15 minutes before a meal. Humalog can be taken right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. The safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog, Humalog Mix75/25, or Humalog Mix50/50 in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

For other important information, see the Patient Information. Please see full user manual that accompanies the pen.

Humalog^® and Humalog^® KwikPen^™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information.

Humalog^® is a registered trademark of Eli Lilly and Company and is available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog^®, Humalog^® KwikPen^™, and HumaPen^® LUXURA^™ are registered trademarks of Eli Lilly and Company.

Humalog^®, Humalog^® KwikPen^™, and HumaPen^® LUXURA^™ HD are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog^® and Humalog^® KwikPen^™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Humalog^® Mix75/25^™, Humalog^® Mix50/50^™, Humalog^® Mix75/25^™ KwikPen^™, and Humalog^® Mix50/50^™ KwikPen^™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog^®, Humalog^® KwikPen^™, HumaPen^® MEMOIR^™, and HumaPen^® LUXURA^™ are registered trademarks of Eli Lilly and Company.

Humalog^®, Humalog^® KwikPen^™, HumaPen^® MEMOIR^™, and HumaPen^® LUXURA^™ HD are available by prescription only.

Humalog^® Mix75/25^™ and Humalog^® Mix50/50^™ are trademarks of Eli Lilly and Company and are available by prescription only.