Questions About Using HumaPen® MEMOIR™

Insulin Pen

What should I do if I cannot attach the cartridge holder to the Pen body?
Check that the insulin cartridge is fully inserted into the cartridge holder. Then, make sure the cartridge holder is completely and securely screwed onto the Pen body.

What should I do if the Pen does not turn on? Video
Make sure you are pressing the ON button. If the Pen does not turn on, contact the Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or your healthcare provider.

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What should I do if I want to turn the Pen off? Video
To prevent your Pen from accidentally being turned off during an injection, there is no OFF button. Your Pen will not turn off unless the display is in READY MODE. The Pen will automatically turn off after 30 seconds of inactivity.

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What should I do if a part of the Pen display is missing or stays on all the time? Video
Your display is not working correctly. Contact the Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or your healthcare provider.

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What should I do if insulin does not come out when I prime the Pen? Video
The needle may be clogged, the cartridge holder may not be completely screwed on, or the foot of the injection screw may not be against the cartridge plunger. You may not be able to see the foot of the injection screw, but repeating the priming step will move it to touch the plunger.

Priming until you see a stream of insulin will ensure that the foot of the injection screw is against the cartridge plunger.

  1. Repeat the priming steps until a stream of insulin is seen.
  2. If you do not see a stream of insulin after several attempts, attach a new needle.
  3. Repeat the priming steps until a stream of insulin is seen.
  4. If you are still unable to get insulin flowing out of the needle, do NOT use the Pen. Contact the Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or your healthcare provider.

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What should I do if there is an air bubble in the cartridge after I prime? Video
Hold the Pen with the needle facing upwards and pointing away from your face. Tap the insulin cartridge holder gently with your finger so any air bubbles can collect near the top. Repeat the priming step. A small air bubble may remain in the cartridge after the completion of the priming step. If you have properly primed the Pen, this small air bubble will not affect your insulin dose.

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What should I do if insulin comes out when I dial backwards? Video
The dose knob may have been accidentally pushed when dialing backwards. To avoid this, do NOT push the dose knob when dialing backwards. Only push the dose knob when injecting.

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What should I do if the dose knob does not go to 0 when I inject my dose? Video
Your cartridge may not have had enough insulin for your entire dose. The number in the display window is the amount you did NOT receive. To get the rest of your dose: Dial down to 0. This will save the first injection in dose memory and return the Pen to READY MODE. Next, change the insulin cartridge, prime the Pen, and inject only the dose amount that you did not receive.

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What should I do if it is difficult to push down the dose knob when I try to inject? Video

  1. Pressing the dose knob down quickly may make the button harder to push. Pressing the dose knob more slowly may make it easier.
  2. Pressing on the side of the dose knob may make it harder to inject. Be sure to press straight in on the dose knob.
  3. The force required to push the dose knob depends on the needle diameter. See your healthcare provider to determine which needle diameter is best for you.
  4. The dose knob may become harder to push if foreign material (dirt, dust), insulin, or other liquids get inside the Pen. Replace the Pen if the dose knob gets too hard to push.

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How much insulin does the Pen hold?
The Pen can only be used with Humalog® 3 mL (100 U/mL) cartridges, which are filled with enough insulin to ensure the delivery of 300 units.

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How and where should I store the Pen?

  • Keep the Pen away from dust, extreme hot or cold (freezing) temperatures and direct sunlight.
  • Do NOT store the Pen in the refrigerator.
  • Keep the Pen and case away from water, moisture or wet surfaces as Pen and case are not watertight.
  • For your insulin cartridge, refer to Humalog Patient Information for complete storage instructions.

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HumaPen MEMOIR is available by prescription only.

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Indication
Humalog is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog (insulin lispro injection [rDNA origin]) is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in Humalog.

Humalog is an injectable, fast-acting insulin. Humalog starts working faster than other insulins that contain regular human insulin. Take Humalog within 15 minutes before eating or right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole-body allergic reactions are less common, but may be life threatening.

Pumps
When used in an external insulin pump, Humalog should not be diluted or mixed with any other insulin. Humalog administration in insulin pumps has not been studied in patients with type 2 diabetes. The infusion set and Humalog should be replaced and a new infusion site selected every 48 hours or less. Glucose monitoring is particularly important for patients using an external insulin pump. Humalog in the external pump should not be exposed to temperatures above 37°C (98.6°F).

Humalog was tested in the MiniMed® Models 506, 507, and 508 insulin pumps using MiniMed® Polyfin® infusion sets.

Humalog was also tested in Disetronic® H-TRONplus® V100 insulin pump (with plastic 3.15 mL insulin reservoir), and the Disetronic D-TRON® and D-TRONplus® insulin pumps (with Humalog 3 mL cartridges) using Disetronic Rapid® infusion sets. A Humalog 3 mL cartridge used in the D-TRON or D-TRONplus should be discarded after 7 days, even if it still contains Humalog. Infusion sets, D-TRON and D-TRONplus cartridge adapters, and Humalog in the external insulin pump reservoir should be discarded every 48 hours or less.

Humalog (insulin lispro injection [rDNA origin]), Humalog Mix75/25 (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog Mix50/50 (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in these insulins.

Humalog is an injectable, fast-acting insulin. Humalog Mix75/25 and Humalog Mix50/50 are a mixture of fast-acting and longer-acting insulins. These insulins start working faster than other insulins that contain regular human insulin. Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be taken within 15 minutes before a meal. Humalog can be taken right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. The safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog, Humalog Mix75/25, or Humalog Mix50/50 in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole-body allergic reactions are less common, but may be life threatening.

For other important information, see the Patient Information. Please see full user manual that accompanies the pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, and HumaPen® LUXURA™ HD are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Patient Information. Please see full user manual that accompanies the pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Managing Your Diabetes® is a registered trademark of Eli Lilly and Company.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Reference
  1. Venekamp WJ, Kerr L, Dowsett SA, et al. Functionality and acceptability of a new electronic insulin injection pen with a memory feature. Curr Med Res Opin. 2006;(22):315-325.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

Reference
  1. Data on file, Lilly USA, LLC (HUM20071024A).

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.