Questions About Using HumaPen® LUXURA™ HD

Preefilled Pen

Why doesn't the screw move out when there is no cartridge in the Pen? Video
The screw may not move out when you push the injection button unless there is a cartridge in the Pen. This feature of the Pen allows you to easily push the screw into the Pen body when replacing a cartridge. Once a cartridge is inserted, the screw will move out when the injection button is pushed.

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What should I do if I can't attach the cartridge holder to the Pen body? Video
Check that the insulin cartridge is fully inserted into the cartridge holder. Then carefully line up the cartridge holder with the Pen body and screw together until secure.

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Why is it important to prime before every injection? Video
If you do NOT prime, you may get too much or too little insulin. Priming helps to ensure that the Pen and needle are working properly. Once the Pen is properly primed, a stream of insulin will flow from the needle. You may need to prime several times before you see a stream of insulin.

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Why can it take several attempts to prime when a new cartridge is inserted? Video
There may be a gap between the screw and the cartridge plunger. Repeating the priming steps will move the screw out to touch the cartridge plunger. Once the end of the screw pushes the cartridge plunger out, insulin will flow from the needle.

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Why should I prime to a stream, and why isn't the Pen ready for use if I see a drop of insulin on the needle tip? Video
Priming moves the screw into contact with the cartridge plunger and gets the air out of the cartridge. When you are priming your Pen:

  • You may see a drop of insulin on the tip of the needle when you first attach it. This only shows that the needle is attached and not clogged. You must still prime the Pen.
  • You may also see no flow at all. This may be because the screw is moving forward to close a gap between the screw and the cartridge plunger.
  • If there is air in the cartridge, the insulin may sputter or drip until all the air is removed.
  • Insulin will flow as a stream only when the Pen is properly primed.
  • If the injection button is hard to push, the needle may be clogged. Attach a new needle. Repeat the priming steps until a stream of insulin is seen.

If you are still unable to see a stream of insulin out of the needle, do NOT use the Pen. Contact Lilly at 1-800-LillyRx (1-800-545-5979) or your healthcare provider for assistance or to obtain a replacement.

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What should I do if I have an air bubble in the cartridge? Video
Priming your Pen will remove air. Point the Pen up, and tap the cartridge gently with your finger so any air bubbles can collect near the top. Repeat the priming steps until a stream of insulin is seen. A small air bubble may remain in the cartridge after completion of the priming steps. If you have properly primed the Pen, this small air bubble will not affect your insulin dose.

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Why is it difficult to push the injection button when I try to inject? Video

  • Your needle may be clogged. Try attaching a new needle, and then prime the Pen.
  • Pushing the injection button down quickly may make the button harder to push. Pushing the button more slowly may make it easier.
  • Using a larger diameter needle will make it easier to push the injection button during injection. Ask your healthcare provider which needle is best for you.

If none of the above steps resolves the problem, your Pen may need to be replaced.

Your injection button may also become harder to push if the inside of your Pen gets dirty with insulin, food, drink or other materials. Following the Care and Storage instructions in your User Manual should prevent this.

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Why doesn't the dose knob go to zero when I inject my dose? Video
This can happen if the Humalog® insulin cartridge does not have enough insulin left in it for your entire dose. The number in the dose window is the amount you did NOT receive. To get the rest of your dose, remove the needle, change the insulin cartridge, attach a new needle and prime the Pen. Then complete your dose by dialing the amount that you did NOT receive and inject only this amount.

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How much insulin does the Pen hold?
The Pen can only be used with Humalog 3 mL (100 U/mL) cartridges, which are filled with enough insulin to ensure the delivery of 300 units.

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How and where should I store the Pen?

  • Remove the needle after every use. Do not store the Pen with the needle attached.
  • Keep the Pen away from moisture, dust, extreme hot or cold temperatures, and direct sunlight.
  • Do not store the Pen in a refrigerator.
  • Refer to the Humalog insulin cartridge Patient Information for complete insulin storage instructions.

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HumaPen LUXURA HD is available by prescription only.

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Indication
Humalog is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog (insulin lispro injection [rDNA origin]) is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in Humalog.

Humalog is an injectable, fast-acting insulin. Humalog starts working faster than other insulins that contain regular human insulin. Take Humalog within 15 minutes before eating or right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole-body allergic reactions are less common, but may be life threatening.

Pumps
When used in an external insulin pump, Humalog should not be diluted or mixed with any other insulin. Humalog administration in insulin pumps has not been studied in patients with type 2 diabetes. The infusion set and Humalog should be replaced and a new infusion site selected every 48 hours or less. Glucose monitoring is particularly important for patients using an external insulin pump. Humalog in the external pump should not be exposed to temperatures above 37°C (98.6°F).

Humalog was tested in the MiniMed® Models 506, 507, and 508 insulin pumps using MiniMed® Polyfin® infusion sets.

Humalog was also tested in Disetronic® H-TRONplus® V100 insulin pump (with plastic 3.15 mL insulin reservoir), and the Disetronic D-TRON® and D-TRONplus® insulin pumps (with Humalog 3 mL cartridges) using Disetronic Rapid® infusion sets. A Humalog 3 mL cartridge used in the D-TRON or D-TRONplus should be discarded after 7 days, even if it still contains Humalog. Infusion sets, D-TRON and D-TRONplus cartridge adapters, and Humalog in the external insulin pump reservoir should be discarded every 48 hours or less.

Humalog (insulin lispro injection [rDNA origin]), Humalog Mix75/25 (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog Mix50/50 (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in these insulins.

Humalog is an injectable, fast-acting insulin. Humalog Mix75/25 and Humalog Mix50/50 are a mixture of fast-acting and longer-acting insulins. These insulins start working faster than other insulins that contain regular human insulin. Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be taken within 15 minutes before a meal. Humalog can be taken right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. The safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog, Humalog Mix75/25, or Humalog Mix50/50 in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole-body allergic reactions are less common, but may be life threatening.

For other important information, see the Patient Information. Please see full user manual that accompanies the pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, and HumaPen® LUXURA™ HD are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Patient Information. Please see full user manual that accompanies the pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Managing Your Diabetes® is a registered trademark of Eli Lilly and Company.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Reference
  1. Venekamp WJ, Kerr L, Dowsett SA, et al. Functionality and acceptability of a new electronic insulin injection pen with a memory feature. Curr Med Res Opin. 2006;(22):315-325.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

Reference
  1. Data on file, Lilly USA, LLC (HUM20071024A).

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.