Questions About Using Humalog® KwikPen™

Insulin Pen

Why should I use a new needle for each injection? Video
This will help ensure sterility. If needles are reused, you may get the wrong amount of insulin, a clogged needle, or a jammed Pen.

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How much insulin is in the Pen?
Each Pen contains a 3 mL (100 U/mL) cartridge, which is filled with enough insulin to ensure the delivery of 300 units.

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What should I do if I am not sure how much insulin remains in my cartridge? Video
Hold the Pen with the needle end pointing down. The scale on the clear Cartridge Holder shows an estimate of the number of units remaining. These numbers should NOT be used for measuring an insulin dose.

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Why should I prime my Pen before each dose? Video

  1. Ensures that the Pen is ready to dose.
  2. Confirms that a stream of insulin comes out of the tip of the needle when you push the Dose Knob in.
  3. Removes air that may collect in the needle or insulin cartridge during normal use.

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What should I do if I cannot completely push in the Dose Knob when priming the Pen? Video

  1. Attach a new needle.
  2. Prime the Pen.

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What should I do if I see an air bubble in the cartridge? Video
You need to prime the Pen. Remember, do not store the Pen with the needle attached as this may cause air bubbles to collect in the insulin cartridge. A small air bubble will not affect your dose and you can continue to take your dose as usual.

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Why is it difficult to push the Dose Knob when I try to inject? Video

  1. Your needle may be clogged. Try attaching a new needle. When you do this you may see insulin come out of the needle. Then prime the Pen.
  2. Pressing the Dose Knob quickly may make the Dose Knob harder to push. Pressing the Dose Knob more slowly may make it easier.
  3. Using a larger diameter needle will make it easier to push the Dose Knob during your injection. See your healthcare provider to determine which needle size is best for you.
  4. If the Dose Knob continues to be difficult to push after following the steps above, try the steps below under "What should I do if my Pen is jammed?".

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What should I do if my Pen is jammed?
Your Pen may be jammed if it is difficult to inject a dose or dial a dose. To clear the jam:

  1. Attach a new needle. When you do this you may see insulin come out of the needle.
  2. Prime the Pen.
  3. Dial your dose and inject.
  4. If the Dose Knob is still difficult to push, contact the Lilly Answers Center at 1-800-Lilly-Rx (1-800-545-5979).

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Why is insulin leaking from the needle after I finished injecting my dose? Video
You may have removed the needle from your skin too quickly.

  1. Make sure you see a 0 in the Dose Window to confirm you received the complete dose.
  2. For the next dose, push and hold the Dose Knob in and count to 5 slowly before removing the needle.

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What should I do if my dose is dialed and the Dose Knob is accidentally pushed in without a needle attached? Video

  1. Dial back to zero.
  2. Attach a new needle. When you do this you may see insulin come out of the needle.
  3. Prime the Pen.
  4. Dial your dose and inject.

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What should I do if I dial a wrong dose (too high or too low)? Video
Turn the Dose Knob backward or forward to correct the dose before injecting.

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What should I do if I see insulin leaking from the Pen needle while dialing the dose or correcting the dose? Video
Do not inject the dose because you may not get your complete dose. Dial the Pen down to zero and prime the Pen again. Dial your dose and inject.

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What should I do if my full dose cannot be dialed? Video
The Pen will not allow you to dial a dose greater than the number of insulin units remaining in the cartridge. For example, if you need 31 units and only 25 units remain in the cartridge you will not be able to dial past 25. Do not attempt to dial past this point. You may either:

  1. Inject the partial dose and then inject the remaining dose using a new Pen.
    or
  2. Inject the full dose with a new Pen.

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Why can I not dial the dose to use the small amount of insulin that remains in my cartridge? Video
The Pen is designed to deliver at least 300 units of insulin. The Pen design prevents the cartridge from being completely emptied because the small amount of insulin that remains in the cartridge cannot be delivered.

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How and where should I store my Pen?

  • Pens that have not been used should be stored in a refrigerator but not in a freezer. Do not use a Pen if it has been frozen.
  • Do not store the Pen with the needle attached. If the needle remains attached, insulin may leak from the Pen, insulin may dry inside the needle causing the needle to clog, or air bubbles may form inside the cartridge.
  • The Pen you are currently using should be kept at room temperature and away from heat and light.
  • Keep the Pen out of the reach of children.
  • Dispose of used needles in a puncture-resistant container or as directed by your healthcare provider.
  • Dispose of used Pens as instructed by your healthcare provider and without the needle attached.

Humalog KwikPen should be discarded 28 days after first use. Humalog® Mix75/25™ KwikPen™ and Humalog® Mix50/50™ KwikPen™ should be discarded 10 days after first use. Be sure to also check the expiration date printed on the Pen's label. The date must allow enough time for you to use all the insulin in the Pen.

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Next
Indication
Humalog is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog (insulin lispro injection [rDNA origin]) is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in Humalog.

Humalog is an injectable, fast-acting insulin. Humalog starts working faster than other insulins that contain regular human insulin. Take Humalog within 15 minutes before eating or right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole-body allergic reactions are less common, but may be life threatening.

Pumps
When used in an external insulin pump, Humalog should not be diluted or mixed with any other insulin. Humalog administration in insulin pumps has not been studied in patients with type 2 diabetes. The infusion set and Humalog should be replaced and a new infusion site selected every 48 hours or less. Glucose monitoring is particularly important for patients using an external insulin pump. Humalog in the external pump should not be exposed to temperatures above 37°C (98.6°F).

Humalog was tested in the MiniMed® Models 506, 507, and 508 insulin pumps using MiniMed® Polyfin® infusion sets.

Humalog was also tested in Disetronic® H-TRONplus® V100 insulin pump (with plastic 3.15 mL insulin reservoir), and the Disetronic D-TRON® and D-TRONplus® insulin pumps (with Humalog 3 mL cartridges) using Disetronic Rapid® infusion sets. A Humalog 3 mL cartridge used in the D-TRON or D-TRONplus should be discarded after 7 days, even if it still contains Humalog. Infusion sets, D-TRON and D-TRONplus cartridge adapters, and Humalog in the external insulin pump reservoir should be discarded every 48 hours or less.

Humalog (insulin lispro injection [rDNA origin]), Humalog Mix75/25 (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog Mix50/50 (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in these insulins.

Humalog is an injectable, fast-acting insulin. Humalog Mix75/25 and Humalog Mix50/50 are a mixture of fast-acting and longer-acting insulins. These insulins start working faster than other insulins that contain regular human insulin. Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be taken within 15 minutes before a meal. Humalog can be taken right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. The safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog, Humalog Mix75/25, or Humalog Mix50/50 in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole-body allergic reactions are less common, but may be life threatening.

For other important information, see the Patient Information. Please see full user manual that accompanies the pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, and HumaPen® LUXURA™ HD are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Patient Information.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company.

For other important information, see the Patient Information. Please see full user manual that accompanies the pen.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Managing Your Diabetes® is a registered trademark of Eli Lilly and Company.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

For other important information, see the Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Reference
  1. Venekamp WJ, Kerr L, Dowsett SA, et al. Functionality and acceptability of a new electronic insulin injection pen with a memory feature. Curr Med Res Opin. 2006;(22):315-325.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

Reference
  1. Data on file, Lilly USA, LLC (HUM20071024A).

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information. Please see full user manual that accompanies each pen.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.