Insulin Storage and Disposal

Humalog Humalog Logo Humalog Humalog 75/25 Mix Humalog Humalog 50/50 Mix

When Humalog®, Humalog® Mix75/25, and Humalog® Mix50/50 insulins are not handled and stored correctly, they may not work the way they should. Click the links below to view some important storage and disposal information. For full storage and disposal information, please see the Patient Information leaflet that comes with your insulin.

Storage and disposal information for vials

  • Store all unopened (unused) vials in the original carton in a refrigerator. Do not freeze
  • Unopened, refrigerated vials can be kept until expiration date
  • After first use (opened), store vial in the refrigerator (not the freezer) or, if necessary, at room temperature below 86°F (30°C). Do not use if vial has been frozen
  • Throw away opened vials 28 days after first use, even if there is insulin left in the vial
  • Do not use after the expiration date printed on the carton and label
  • Protect from direct heat and light

Safely dispose of needles and syringes as directed by your healthcare provider.

Storage and disposal information for prefilled pens

  • Store all unopened (unused) prefilled pens in the original carton in a refrigerator. Do not freeze
  • Unopened, refrigerated pens can be kept until the expiration date
  • After first use, do not store in the refrigerator. Keep at room temperature below 86°F (30°C)
  • For Humalog prefilled pens: Throw away your Humalog prefilled pen 28 days after first use, even if there is insulin left in it
  • For Humalog Mix75/25 or Humalog Mix50/50 prefilled pens: Throw away your Humalog Mix75/25 or Humalog Mix50/50 prefilled pen 10 days after first use, even if there is insulin left
    in it
  • Do not use after the expiration date printed on the carton and label
  • Protect pens from direct heat and light
  • Dispose of needles and pens as directed by your healthcare provider

Disposal of needles and syringes

  • Place all needles and syringes in a sharps disposal container immediately after they have been used
    • -Never place loose needles in any trash can or recycling bin and never flush them down the toilet
    • -Carry a small, travel-size sharps disposal container when leaving home
  • Dispose of the sharps container according to community guidelines
    • -Do not reuse sharps containers

For information about disposal of syringes and needles, visit the U.S. Food and Drug Administration website at www.fda.gov/safesharpsdisposal.

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Title Place Holder

Who should use Humalog?

Humalog is used to treat people with diabetes for the control of high blood sugar.

Important Safety Information for Humalog

What is the most important information I should know about Humalog?

  • Do not change the insulin you use without talking to your healthcare provider. Doses of oral antidiabetic medicines may also need to change if your insulin is changed.
  • Test your blood sugar levels as your healthcare provider instructs.
  • When used in a pump, do not mix Humalog with any other insulin or liquid.

Who should not take Humalog?

  • Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog.

Before using Humalog, what should I tell my healthcare providers?

Tell your healthcare providers:

  • About all of your medical conditions, including liver, kidney, or heart problems.
  • If you are pregnant or breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and non-prescription medicines, vitamins, and herbal supplements.

How should I use Humalog?

  • Humalog is a rapid-acting insulin. Take Humalog within fifteen minutes before eating or right after eating a meal.
  • Always make sure you receive the correct type of Humalog from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not mix Humalog with insulin other than NPH when using a syringe. Do not mix or dilute Humalog when used in a pump.
  • Inject Humalog under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Depending on the type of diabetes you have, you may need to take Humalog with a longer-acting insulin or with oral antidiabetic medicines.
  • If you forget to take your dose of Humalog, your blood sugar may go too high (hyperglycemia), which can lead to serious problems like loss of consciousness (passing out), coma, or even death.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.

What are the possible side effects of Humalog?

  • Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much Humalog. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. If severe, low blood sugar can cause unconsciousness (passing out), seizures, and death. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your healthcare provider. Do not inject insulin into a skin area that is red, swollen, or itchy.
  • Skin may thicken or pit at the injection site (lipodystrophy). Do not inject insulin into skin with these types of changes.
  • Other side effects include low potassium in your blood (hypokalemia), and weight gain.
  • Serious side effects can include:
    • swelling of your hands and feet
    • heart failure when taking certain pills called thiazolidinediones or "TZDs" with Humalog. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs or Humalog.
  • These are not all of the possible side effects. Ask your healthcare providers for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store Humalog?

  • Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.
  • Humalog should be stored away from light and heat. Do not use insulin if it has been frozen.
  • Opened vials should be kept at room temperature or in a refrigerator. Opened cartridges or prefilled pens should be kept at room temperature.
  • Once opened, Humalog vials, prefilled pens, and cartridges should be thrown away after 28 days.

Humalog is available by prescription only.

For additional information, talk to your healthcare providers and please click to access Full Prescribing Information and Patient Prescribing Information.

Please see Instructions for Use that accompanies your pen.

HI CON ISI 29MAR2013

Humalog® and Humalog® KwikPen are registered trademarks of Eli Lilly and Company and are available by prescription only.

Who should use Humalog, Humalog Mix75/25, and Humalog Mix50/50?

Humalog is used to treat people with diabetes for the control of blood sugar. Humalog Mix75/25 and Humalog Mix50/50 are used to treat adults with diabetes for the control of high blood sugar.

Important Safety Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50

What is the most important information I should know about Humalog, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not change the insulin you use without talking to your healthcare provider. Doses of oral antidiabetic medicines may also need to change if your insulin is changed.
  • Test your blood sugar levels as your healthcare provider instructs.
  • When used in a pump, do not mix Humalog with any other insulin or liquid. Never use Humalog Mix75/25 or Humalog Mix50/50 in a pump.

Who should not take Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.

Before using Humalog, Humalog Mix75/25, or Humalog Mix50/50, what should I tell my healthcare providers?

Tell your healthcare providers:

  • About all of your medical conditions, including liver, kidney, or heart problems.
  • If you are pregnant or breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and non-prescription medicines, vitamins, and herbal supplements.

How should I use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating.
  • Always make sure that you receive the correct type of insulin from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or milky after mixing.
  • Do not mix Humalog with insulin other than NPH when using a syringe. Do not mix or dilute Humalog when used in a pump.
  • Never mix Humalog Mix75/25 or Humalog Mix50/50 in the same syringe with other insulin products. Never use Humalog Mix75/25 or Humalog Mix50/50 in a pump.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Depending on the type of diabetes you have, you may need to take Humalog with a longer-acting insulin or with oral antidiabetic medications.
  • If you forget to take your insulin, your blood sugar may go too high (hyperglycemia), which can lead to serious problems like loss of consciousness (passing out), coma, or even death.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.

What are the possible side effects of Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much insulin. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. If severe, low blood sugar can cause unconsciousness (passing out), seizures, and death. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your healthcare provider. Do not inject insulin into a skin area that is red, swollen, or itchy.
  • Skin may thicken or pit at the injection site (lipodystrophy). Do not inject insulin into skin with these types of changes.
  • Other side effects include low potassium in your blood (hypokalemia), and weight gain.
  • Serious side effects can include:
    • swelling of your hands and feet
    • heart failure when taking certain pills called thiazolidinediones or "TZDs" with Humalog, Humalog Mix75/25, or Humalog Mix50/50. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs, Humalog, Humalog Mix75/25, or Humalog Mix50/50.
  • These are not all of the possible side effects. Ask your healthcare providers for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store Humalog, Humalog Mix75/25, and Humalog Mix50/50?

  • Unopened Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be stored in a refrigerator and can be used until the expiration date on the carton or label.
  • Insulin should be stored away from light and heat. Do not use insulin if it has been frozen.
  • Opened vials should be kept at room temperature or in a refrigerator. Opened cartridges or prefilled pens should be kept at room temperature.
  • Once opened, Humalog vials, prefilled pens, and cartridges should be thrown away after 28 days.
  • Once opened, Humalog Mix75/25 and Humalog Mix50/50 vials should be thrown away after 28 days. Opened Humalog Mix75/25 and Humalog Mix50/50 prefilled pens should be thrown away after 10 days.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are available by prescription only.

For additional information, talk to your healthcare providers and please click to access Full Prescribing Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50, and Patient Prescribing Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50.

Please see Instructions for Use that accompanies your pen.

HI BOI CON ISI 29MAR2013

Humalog® and Humalog® KwikPen are registered trademarks of Eli Lilly and Company and are available by prescription only.

Humalog® Mix75/25, Humalog® Mix50/50, Humalog® Mix75/25 KwikPen, and Humalog® Mix50/50 KwikPen are trademarks of Eli Lilly and Company and are available by prescription only.

Who should use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

Humalog is used to treat people with diabetes for the control of blood sugar. Humalog Mix75/25 and Humalog Mix50/50 are used to treat adults with diabetes for the control of high blood sugar. These insulins contain 100 units per mL.

Humalog is used to treat people with diabetes for the control of blood sugar. Humalog Mix75/25 (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog Mix50/50 (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are used to treat adults with diabetes for the control of high blood sugar. These insulins contain 100 units per mL.

What is some select safety Information I should know about Humalog, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not take Humalog, Humalog Mix75/25, or Humalog Mix50/50 if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.
  • Do not change the insulin you use without talking to your healthcare provider.
  • Low blood sugar (hypoglycemia) is a possible side effect of Humalog, Humalog Mix75/25, and Humalog Mix50/50 that may be severe and cause unconsciousness (passing out), seizures, and death. Test your blood sugar levels as your healthcare provider instructs.
  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 start working faster than other insulins that contain regular human insulin and should be taken within fifteen minutes before eating. Humalog can also be taken right after eating a meal.

Important Safety Information for Humalog®, Humalog® Mix75/25, and Humalog® Mix50/50

What is the most important information I should know about Humalog, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not change the insulin you use without talking to your healthcare provider. Doses of oral antidiabetic medicines may also need to change if your insulin is changed.
  • Test your blood sugar levels as your healthcare provider instructs.
  • When used in a pump, do not mix Humalog with any other insulin or liquid. Never use Humalog Mix75/25 or Humalog Mix50/50 in a pump.

Who should not take Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.

Before using Humalog, Humalog Mix75/25, or Humalog Mix50/50, what should I tell my healthcare providers?

  • About all of your medical conditions, including liver, kidney, or heart problems.
  • If you are pregnant or breastfeeding.
  • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and nonprescription medicines, vitamins, and herbal supplements.

How should I use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating.
  • Always make sure that you receive the correct type of insulin from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or milky after mixing.
  • Do not mix Humalog with insulin other than NPH when using a syringe. Do not mix or dilute Humalog when used in a pump.
  • Never mix Humalog Mix75/25 or Humalog Mix50/50 in the same syringe with other insulin products. Never use Humalog Mix75/25 or Humalog Mix50/50 in a pump.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Depending on the type of diabetes you have, you may need to take Humalog with a longer-acting insulin or with oral antidiabetic medications.
  • If you forget to take your insulin, your blood sugar may go too high (hyperglycemia), which can lead to serious problems such as loss of consciousness (passing out), coma, or even death.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.

What are the possible side effects of Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much insulin. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. If severe, low blood sugar can cause unconsciousness (passing out), seizures, and death. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your healthcare provider. Do not inject insulin into a skin area that is red, swollen, or itchy.
  • Skin may thicken or pit at the injection site (lipodystrophy). Do not inject insulin into skin with these types of changes.
  • Other side effects include low potassium in your blood (hypokalemia) and weight gain.
  • Serious side effects can include swelling of your hands and feet and heart failure when taking certain pills called thiazolidinediones or “TZDs” with Humalog, Humalog Mix75/25, or Humalog Mix50/50. This may occur in some people even if they have not had heart problems before. Tell your healthcare provider if you have shortness of breath, swelling of your ankles or feet, or sudden weight gain, which may be symptoms of heart failure. Your healthcare provider may need to adjust or stop your treatment with TZDs, Humalog, Humalog Mix75/25, or Humalog Mix50/50.
  • These are not all of the possible side effects. Ask your healthcare providers for more information or for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are available by prescription only.

For additional information, talk to your healthcare providers and please click to access Full Prescribing Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50, and Patient Prescribing Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50.

Please see Instructions for Use that accompany your pen.

HI BOI CON ISI 31JAN2014