Who should use Humalog?

Humalog® is used to treat people with diabetes for the control of high blood sugar.

What is some select safety information I should know about Humalog?

  • Do not take Humalog if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in Humalog.
  • Do not change the insulin you use without talking to your healthcare provider.
  • Low blood sugar (hypoglycemia) is a possible side effect of Humalog which may be severe and cause unconsciousness (passing out), seizures, and death. You must test your blood sugar levels while using Humalog.
  • Humalog is a rapid-acting insulin. Take Humalog within fifteen minutes before eating or right after eating a meal.

Click here for additional Important Safety Information for Humalog.

Who should use glucagon?

Glucagon for injection (rDNA origin) is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).

What is some select safety information I should know about glucagon?

  • Glucagon should not be used if you have pheochromocytoma or if you are allergic to glucagon.
  • Make sure you tell your healthcare provider if you have been diagnosed with or have been suspected of having an insulinoma as glucagon should be used cautiously in this situation.
  • Make sure that your relatives or close friends know that if you become unconscious, medical assistance must always be sought. If you are unconscious, glucagon can be given while awaiting medical assistance.

Click here for additional Important Safety Information for glucagon.

Who should use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

Humalog®, Humalog® Mix75/25™, and Humalog® Mix50/50™ are used to treat people with diabetes for the control of high blood sugar.

Humalog®, Humalog® Mix75/25™ (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog® Mix50/50™ (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are used to treat people with diabetes for the control of high blood sugar.

What is some select safety Information I should know about Humalog, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not take Humalog, Humalog Mix75/25, or Humalog Mix50/50 if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.
  • Do not change the insulin you use without talking to your healthcare provider.
  • Low blood sugar (hypoglycemia) is a possible side effect of Humalog, Humalog Mix75/25, and Humalog Mix50/50 which may be severe and cause unconsciousness (passing out), seizures, and death. You must test your blood sugar levels while using Humalog, Humalog Mix75/25, or Humalog Mix50/50.
  • Humalog, Humalog Mix75/25, and Humalog Mix50/50 start working faster than other insulins that contain regular human insulin and should be taken within fifteen minutes before eating. Humalog can also be taken right after eating a meal.

Click here for additional Important Safety Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50.

Who should use glucagon?

Glucagon for injection (rDNA origin) is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).

What is some select safety information I should know about glucagon?

  • Glucagon should not be used if you have pheochromocytoma or if you are allergic to glucagon.
  • Make sure you tell your healthcare provider if you have been diagnosed with or have been suspected of having an insulinoma as glucagon should be used cautiously in this situation.
  • Make sure that your relatives or close friends know that if you become unconscious, medical assistance must always be sought. If you are unconscious, glucagon can be given while awaiting medical assistance.

Click here for additional Important Safety Information for glucagon.

Questions About Using HumaPen LUXURA HD

Why doesn't the screw move out when there is no cartridge in the pen?

The screw may not move out when you push the injection button unless there is a cartridge in the pen. This feature of the pen allows you to easily push the screw into the pen body when replacing a cartridge. Once a cartridge is inserted, the screw will move out when the injection button is pushed.

What should I do if I can't attach the cartridge holder to the pen body?

Check that the insulin cartridge is fully inserted into the cartridge holder. Then carefully line up the cartridge holder with the pen body and screw together until secure.

Why is it important to prime before every injection?

If you do NOT prime, you may get too much or too little insulin. Priming helps to ensure that the pen and needle are working properly. Once the pen is properly primed, a stream of insulin will flow from the needle. You may need to prime several times before you see a stream of insulin.

Why can it take several attempts to prime when a new cartridge is inserted?

There may be a gap between the screw and the cartridge plunger. Repeating the priming steps will move the screw out to touch the cartridge plunger. Once the end of the screw pushes the cartridge plunger out, insulin will flow from the needle.

Why should I prime to a stream, and why isn't the pen ready for use if I see a drop of insulin on the needle tip?

Priming moves the screw into contact with the cartridge plunger and gets the air out of the cartridge. When you are priming your pen:

  • You may see a drop of insulin on the tip of the needle when you first attach it. This only shows that the needle is attached and not clogged. You must still prime the pen
  • You may also see no flow at all. This may be because the screw is moving forward to close a gap between the screw and the cartridge plunger
  • If there is air in the cartridge, the insulin may sputter or drip until all the air is removed
  • Insulin will flow as a stream only when the pen is properly primed
  • If the injection button is hard to push, the needle may be clogged. Attach a new needle. Repeat the priming steps until a stream of insulin is seen

If you are still unable to see a stream of insulin out of the needle, do NOT use the pen. Contact The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or your healthcare provider for assistance or to obtain a replacement.

What should I do if I have an air bubble in the cartridge?

Priming your pen will remove air. Point the pen up, and tap the cartridge gently with your finger so any air bubbles can collect near the top. Repeat the priming steps until a stream of insulin is seen. A small air bubble may remain in the cartridge after completion of the priming steps. If you have properly primed the pen, this small air bubble will not affect your insulin dose.

Why is it difficult to push the injection button when I try to inject?

  • Your needle may be clogged. Try attaching a new needle, and then prime the pen
  • Pushing the injection button down quickly may make the button harder to push. Pushing the button more slowly may make it easier
  • Using a larger diameter needle will make it easier to push the injection button during injection. Ask your healthcare provider which needle is best for you

If none of the above steps resolves the problem, your pen may need to be replaced.

Your injection button may also become harder to push if the inside of your pen gets dirty with insulin, food, drink or other materials. Following the Care and Storage instructions in your user manual should prevent this.

Why doesn't the dose knob go to zero when I inject my dose?

This can happen if the Humalog insulin cartridge does not have enough insulin left in it for your entire dose. The number in the dose window is the amount you did NOT receive. To get the rest of your dose, remove the needle, change the insulin cartridge, attach a new needle and prime the pen. Then complete your dose by dialing the amount that you did NOT receive and inject only this amount.

How much insulin does the pen hold?

The pen can only be used with Humalog 3 mL (100 units per mL) cartridges, which are filled with enough insulin to ensure the delivery of 300 units.

How and where should I store the pen?

  • Remove the needle after every use. Do not store the pen with the needle attached
  • Keep the pen away from moisture, dust, extreme hot or cold temperatures, and direct sunlight
  • Do not store the pen in a refrigerator
  • Do not store an insulin cartridge that you are using in the refrigerator. Keep at room temperature below 86°F (30°C) for up to 28 days. Throw away a cartridge 28 days after first use, even if there is insulin left in the cartridge

Who should use Humalog®, Humalog® Mix75/25™, or Humalog® Mix50/50™?

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are used to treat people with diabetes for the control of high blood sugar.

Important Safety Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50

What is the most important information I should know about Humalog, Humalog Mix75/25, and Humalog Mix50/50?

  • Do not change the insulin you use without talking to your healthcare provider. Doses of oral antidiabetic medicines may also need to change if your insulin is changed.
  • Test your blood sugar levels as your healthcare provider instructs.
  • When used in a pump, do not mix Humalog with any other insulin or liquid. Never use Humalog Mix75/25 or Humalog Mix50/50 in a pump.

Who should not take Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Do not take these insulins if your blood sugar is too low (hypoglycemia) or if you are allergic to insulin lispro or any of the ingredients in these insulins.

Before using Humalog, Humalog Mix75/25, or Humalog Mix50/50, what should I tell my healthcare providers?

Tell your healthcare providers:

  • About all of your medical conditions, including liver or kidney problems.
  • If you are pregnant or breastfeeding.
  • About all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

How should I use Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • These insulins start working faster than other insulins that contain regular human insulin. You should take Humalog within fifteen minutes before eating or right after eating a meal. You should take Humalog Mix75/25 and Humalog Mix50/50 within fifteen minutes before eating.
  • Always make sure that you receive the correct type of insulin from the pharmacy.
  • Do not use Humalog if it is cloudy, colored, or has solid particles or clumps in it.
  • Do not use Humalog Mix75/25 or Humalog Mix50/50 if they have solid particles or clumps in them. Humalog Mix75/25 and Humalog Mix50/50 should be mixed carefully before each use and should be cloudy or milky after mixing.
  • Do not mix Humalog with insulin other than NPH when using a syringe. Do not mix or dilute Humalog when used in a pump.
  • Never mix Humalog Mix75/25 or Humalog Mix50/50 in the same syringe with other insulin products. Never use Humalog Mix75/25 or Humalog Mix50/50 in a pump.
  • Inject your insulin under your skin (subcutaneously). Never inject into a vein or muscle. Change (rotate) your injection site with each dose. Make sure you inject the correct insulin and dose.
  • Depending on the type of diabetes you have, you may need to take Humalog with a longer-acting insulin or with oral antidiabetic medications.
  • If you forget to take your insulin, your blood sugar may go too high (hyperglycemia), which can lead to serious problems like loss of consciousness (passing out), coma, or even death.
  • Your insulin dose may need to change because of illness, stress, other medicines you take, change in diet, or change in physical activity or exercise.

What are the possible side effects of Humalog, Humalog Mix75/25, or Humalog Mix50/50?

  • Low blood sugar is the most common side effect. There are many causes of low blood sugar, including taking too much insulin. It is important to treat it quickly. You can treat mild to moderate low blood sugar by drinking or eating a quick source of sugar right away. If severe, low blood sugar can cause unconsciousness (passing out), seizures, and death. Symptoms may be different for each person. Be sure to talk to your healthcare provider about low blood sugar symptoms and treatment.
  • Severe life-threatening allergic reactions (whole-body reactions) can happen. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Reactions at the injection site (local allergic reaction) such as redness, swelling, and itching can happen. If you keep having skin reactions or they are serious, talk to your healthcare provider. Do not inject insulin into a skin area that is red, swollen, or itchy.
  • Skin may thicken or pit at the injection site (lipodystrophy). Do not inject insulin into skin with these types of changes.
  • Other side effects include swelling of your hands and feet, low potassium in your blood (hypokalemia), and weight gain.
  • These are not all of the possible side effects. Ask your healthcare providers for more information or for medical advice about side effects.

You are encouraged to report negative side effects of Prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store Humalog, Humalog Mix75/25, and Humalog Mix50/50?

  • Unopened Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be stored in a refrigerator and can be used until the expiration date on the carton or label.
  • Insulin should be stored away from light and heat. Do not use insulin if it has been frozen.
  • Opened vials should be kept at room temperature or in a refrigerator. Opened cartridges or prefilled pens should be kept at room temperature.
  • Once opened, Humalog vials, prefilled pens, and cartridges should be thrown away after 28 days.
  • Once opened, Humalog Mix75/25 and Humalog Mix50/50 vials should be thrown away after 28 days. Opened Humalog Mix75/25 and Humalog Mix50/50 prefilled pens should be thrown away after 10 days.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are available by prescription only.

For additional information, talk to your healthcare providers and please click to access Full Prescribing Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50, and Patient Information for Humalog, Humalog Mix75/25, and Humalog Mix50/50.

Please see full user manual that accompanies the pen.

HI BOI CON ISI 8JUN2011

Who should use glucagon?

Glucagon for injection (rDNA origin) is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).

Important Safety Information for Glucagon

What is the most important information I should know about glucagon?

  • Glucagon should not be used if you have pheochromocytoma or if you are allergic to glucagon.
  • Make sure you tell your healthcare provider if you have been diagnosed with or have been suspected of having an insulinoma as glucagon should be used cautiously in this situation.
  • You and anyone who may need to help you during an emergency should become familiar with how to use glucagon before an emergency arises. Read the Information for the User provided in the kit.
  • Make sure that your relatives or close friends know that if you become unconscious, medical assistance must always be sought. If you are unconscious, glucagon can be given while awaiting medical assistance.
  • Do not use the kit after the date stamped on the bottle label.
  • If you have questions concerning the use of this product, consult a doctor, nurse or pharmacist.

WARNING: YOU MAY BE IN A COMA FROM SEVERE HYPERGLYCEMIA (HIGH BLOOD GLUCOSE) RATHER THAN HYPOGLYCEMIA. IN SUCH A CASE, YOU WILL NOT RESPOND TO GLUCAGON AND REQUIRE IMMEDIATE MEDICAL ATTENTION.

Who should not use glucagon?

Glucagon should not be used if you have pheochromocytoma or if you are allergic to glucagon.

What should I tell my doctor before taking glucagon?

Tell your doctor about all of your medical conditions and prescription and over-the-counter drugs. Tell your doctor if you have been diagnosed with or have been suspected of having pheochromocytoma or an insulinoma.

How should I use glucagon?

  • Act quickly. Prolonged unconsciousness may be harmful.
  • Make sure your family and friends know to turn you on your side to prevent choking if you are unconscious.
  • The contents of the syringe are inactive and must be mixed with the glucagon in the accompanying bottle immediately before giving injection. Do not prepare Glucagon for Injection until you are ready to use it.
  • Glucagon should not be used unless the solution is clear and of a water-like consistency.
  • The usual adult dose is 1 mg (1 unit). For children weighing less than 44 lb (20 kg), give 1/2 adult dose (0.5 mg). For children, withdraw 1/2 of the solution from the bottle (0.5 mg mark on syringe). Discard unused portion.
  • You should eat as soon as you awaken and are able to swallow. Inform a doctor or emergency services immediately.

What is some important Information I should know about Low Blood Sugar (Hypoglycemia)?

  • Early symptoms of low blood sugar include: sweating, drowsiness, dizziness, sleep disturbances, palpitation, anxiety, tremor, blurred vision, hunger, slurred speech, restlessness, depressed mood, tingling in the hands, feet, lips, or tongue, irritability, lightheadedness, abnormal behavior, inability to concentrate, unsteady movement, headache, and personality changes. These symptoms may be different for each person and can happen suddenly.
  • If your low blood sugar is not treated, you may progress to severe low blood sugar that can include: disorientation, seizures, unconsciousness, and death.
  • Low blood sugar symptoms should be treated with a quick source of sugar which should always be carried with you. If you do not improve or you are unable to take a quick source of sugar, you should be treated with glucagon or with intravenous glucose at a medical facility.

What are the possible side effects of glucagon?

  • Severe side effects are very rare, although nausea and vomiting may occur occasionally.
  • A few people may be allergic to glucagon or to one of the inactive ingredients in glucagon, or may experience rapid heart beat for a short while.
  • If you experience any other reactions which are likely to have been caused by glucagon, please contact your doctor.

You are encouraged to report negative side effects of Prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store glucagon?

  • Before dissolving glucagon with diluting solution, store the kit at controlled room temperature between 20° to 25°C (68° to 77°F).
  • After dissolving glucagon with diluting solution, use immediately. Discard any unused portion. Glucagon should be clear and of a water-like consistency at time of use.

For more safety information, please click to access Information for the User and Information for the Physician.

HI GLUC CON ISI 21APR2011

Pens are for single-patient use only and should not be shared among patients.

Humalog® is a registered trademark of Eli Lilly and Company and is available by prescription only.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ are registered trademarks of Eli Lilly and Company.

Humalog®, Humalog® KwikPen™, HumaPen® MEMOIR™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® and Humalog® KwikPen™ are registered trademarks of Eli Lilly and Company and are available by prescription only.

Humalog®, Humalog® KwikPen™, and HumaPen® LUXURA™ HD are available by prescription only.

Humalog® Mix75/25™, Humalog® Mix50/50™, Humalog® Mix75/25™ KwikPen™, and Humalog® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.

Humalog® Mix75/25™ and Humalog® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.

The glucagon design is a trademark of Eli Lilly and Company. Glucagon is available by prescription only.

Managing Your Diabetes® is a registered trademark of Eli Lilly and Company.

Other product names mentioned herein are the trademarks of their respective owners.

You are now leaving Humalog.com

The link you clicked on will take you to a site maintained by a third party, which is solely responsible for its content. Lilly USA, LLC does not control, influence, or endorse this site, and the opinions, claims, or comments expressed on this site should not be attributed to Lilly USA, LLC. Lilly USA, LLC is not responsible for the privacy policy of any third-party websites. We encourage you to read the privacy policy of every website you visit.

Click "Continue" to proceed or "Return" to return to Humalog.com.

For Healthcare Professionals

The information contained in this section of Humalog.com is technical in nature and was specifically created for healthcare professionals. If you are not a healthcare professional, and would like to return to the consumer section of the site, please click the return button below.

Yes, I am a Healthcare Professional and would like to continue.

Please select if you are:

A Parent or Caregiver of
a Child with
Type 1 Diabetes > An Adult with
Type 1 Diabetes >

Please select which user manual
you would like to download:

Humalog KwikPen manual Humalog KwikPen 75/25 manual Humalog KwikPen 50/50 manual

Please select which user manual
you would like to download:

Humalog KwikPen 75/25 manual Humalog KwikPen 50/50 manual